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Recruiting NCT05661318

AHC Ballana Heart Study

Observational Genetic Predisposition to Disease

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Risk assessment.
Who it may be relevant to
Registry conditions: Genetic Predisposition to Disease. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Egypt
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Official title

Aswan Heart Centre - Ballana Heart Study

Overview

This Study is designed to assess CVD incidence, prevalence, progression and related risk factors, including genetic background. It will provide an important base for all cardiovascular research activities in our centre and help in designing future studies and guide policy.

Detailed description

Background Population-based longitudinal studies are a cornerstone in understanding current disease landscapes affecting communities and collecting reliable data to guide prevention and treatment strategies. In Egypt there is pressing need of collecting reliable data on cardiovascular disease (CVD) in defined populations.

Objectives Defining the cardiovascular phenotype, genotype as well as OMICS and risk factors for CVD in a defined population in Egypt with follow up for up to 30 years

Methods As a first step, a random representative sample of 1,200 households from the Ballana population will be created. Following inclusion, patients will be screened for their cardiovascular profile and followed up for changes in their profile and cardiovascular events continuously every year in high risk patients and every 3 years for the rest of the participants for a period of 30 years.

Interventions

  • Other Risk assessment
    Collect clinical, laboratoary and genetics data from the participants after informed consent

Primary outcome measures

  • Cardiovascular risk assessment [Time frame: 30 years]

Eligibility criteria

Inclusion criteria

  • Residents of Ballana from the 1,200 randomly selected households
  • Participants must have a valid National ID card
  • Written informed consent

Exclusion criteria

  • Residents who are younger than 18 years

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Ecologic or community

Study locations

Egypt · 1 center
  • Aswan Heart Centre - Magdi Yacoub Heart Foundation — Aswān

Publications

  • Keates AK, Mocumbi AO, Ntsekhe M, Sliwa K, Stewart S. Cardiovascular disease in Africa: epidemiological profile and challenges. Nat Rev Cardiol. 2017 May;14(5):273-293. doi: 10.1038/nrcardio.2017.19. Epub 2017 Feb 23. PMID 28230175

Identifiers

NCT: NCT05661318 · AHC-BHS

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗