Prediction of Long-term Outcome in Aortic Stenosis After Valve Intervention
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: There is no intervention since it is an observational study patients are treated according to clinical praxis.
- Who it may be relevant to
- Registry conditions: Aortic Stenosis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Sweden
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Biological Valve Prosthesis in Aortic Stenosis - Imaging, Biomarkers, Physical Performance and Patient Related Factors Predictive to Long-term Outcome (Bio-AS)
Overview
Patients with severe aortic stenosis accepted for transcatheter intervention or open surgery are included before the intervention, and then followed up with clinical visits during the first year after intervention. Imaging with echocardiography and computed tomography (CT) are performed together with additional imaging with magnetic resonance imaging (MRI) and Positron emissions tomography (PET)-CT in a subgroup of the study population. Blood samples, physical performance and questionnaires with focus on frailty and heart failure are also collected at each visit. A follow up with information of the outcomes after 2-5 years will be performed through national registries.
Interventions
- Other There is no intervention since it is an observational study patients are treated according to clinical praxis
No intervention
Primary outcome measures
- Semiquantitative assessment of protein levels associated with myocardial performance [Time frame: One year after intervention.]
- Imaging parameters associated with clinical outcome after intervention [Time frame: One year after intervention]
- Semiquantitative assessment of protein levels associated with myocardial performance associated with clinical outcome after intervention [Time frame: Two years after intervention]
Secondary outcome measures (1)
- Imaging parameters associated with clinical outcome after intervention [Time frame: Two years after intervention]
Eligibility criteria
Inclusion criteria
- Accepted for aortic valve intervention
Exclusion criteria
- No able to follow the study protocol
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Cohort
Study locations
Sweden · 1 center
- Department of cardiology Uppsala University Hospital — Uppsala
Identifiers
NCT: NCT05629104 · Bio-AS