Optimization Strategy of Carotid Artery Stenosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Carotid revascularization, MRI-PWI, CTA, PET/MRI.
- Who it may be relevant to
- Registry conditions: Carotid Artery Stenosis. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Cohort of Optimized Assessment Strategy of Carotid Artery Stenosis
Overview
The goal of this observational study is to learn about how to utilize multiple evaluation techniques in carotid artery stenosis patients for optimizing assessment of diagnosis and treatment strategy. The main questions it aims to answer are: * Identify best strategy that use multi-modal MRI and CT to assess patients' cerebral lesions and perfusion. * Identify best strategy that use multi-modal MRI, PET-MRI ultrasound and CT to assess components and characters of patients' carotid plaques. Participants will accept imaging examination before and after surgery. And doctors will collect basic characteristics, imaging results and biological samples of patients for analysis.
Interventions
- Procedure Carotid revascularization
All patients received carotid revascularization surgery at Peking Union Medical College Hospital. - Diagnostic test MRI-PWI
Multi-modal MRI before and after surgery. - Diagnostic test CTA
CTA before and after surgery. - Diagnostic test PET/MRI
PET/MRI before surgery. - Diagnostic test Ultrasound
Ultrasound before and after surgery.
Primary outcome measures
- stroke [Time frame: During hospital stay, usually 7-30 days post operation]
- cardiac infarction [Time frame: During hospital stay, usually 7-30 days post operation]
- transient ischemic attack [Time frame: During hospital stay, usually 7-30 days post operation]
- cerebral hyperperfusion syndrome [Time frame: During hospital stay, usually 7-30 days post operation]
- death [Time frame: During hospital stay, usually 7-30 days post operation]
Secondary outcome measures (4)
- Image characters of MRI [Time frame: half year after operation]
- Image characters of PET/MRI [Time frame: half year after operation]
- Image characters of ultrasound [Time frame: half year after operation]
- Carotid plaque characters [Time frame: half year after operation]
Eligibility criteria
Inclusion criteria
- patients with severe stenosis (≥50%) or near-occlusion diagnosed by computed tomographic angiogram;
- patients received carotid endarterectomy at Peking Union Medical College Hospital
Exclusion criteria
(1) Any contraindication to image examination; (3) refuse to sign the Informed consent.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- vascular surgery department of PUMCH — Beijing
Publications
- Lai Z, Wang C, Liu X, Sun H, Guo Z, Shao J, Li K, Chen J, Wang J, Lei X, Shu K, Feng Y, Kong D, Sun W, Liu B. Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry. J Transl Med. 2024 Mar 7;22(1):247. doi: 10.1186/s12967-023-04723-1. PMID 38454421
Identifiers
NCT: NCT05629000 · PUMCH-CAS-006