Endothelial Glycocalyx Damage in Brain Death Organ Donors
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Endothelial glycocalyx damage assessment.
- Who it may be relevant to
- Registry conditions: Brain Damage Due to Hypoxia, Organ Donors, Organ Transplant Failure or Rejection. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Czechia
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Endothelial Glycocalyx Status and Damage in Brain Death Organ Donors
Overview
The study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ function after transplantation in marginal donors.
Interventions
- Diagnostic test Endothelial glycocalyx damage assessment
Degradation products of endothelial glycocalyx will be assessed in the blood and urine.
Primary outcome measures
- Markers of endothelial glycocalyx damage [Time frame: baseline at the time of inclusion]
Eligibility criteria
Inclusion criteria
- patients in critical condition declared as brain dead by clinical examination
Exclusion criteria
- N/A
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Czechia · 1 center
- University Hospital Hradec Kralove — Hradec Králové
Identifiers
NCT: NCT05609123 · CooperatioUK_DBD_GCX