Comparison of Scores for Early Brain Damage Assessment at Intensive Care Unit Admission After Cardiac Arrest
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Calculation of early prognosis score.
- Who it may be relevant to
- Registry conditions: Cardiac Arrest. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Even in patients with successful return of spontaneous circulation (ROSC), outcome after cardiac arrest remains poor. The overall in-hospital survival rate widely varies both worldwide and across communities, from 1 to 4 folds according to circumstances of arrest and post-resuscitation interventions. Several studies have already shown that early interventions performed after ROSC, such as treatment of the cause, targeted temperature management, optimal hemodynamic management and extra-corporeal life support in selected patients, could improve the outcome in post-cardiac arrest patients. However, the decision process regarding the allocation of these resources, in parallel with the management of patients' proxies, remains a complex challenge for physicians facing these situations. Consequently, several prediction models and scores have been developed in order to stratify the risk of unfavorable outcome and to discriminate the best candidates for post-resuscitation interventions. Overall, several scores exist, but external validation are lacking and direct comparisons are needed to assess relative interest of scoring systems. Indeed, establishing the optimal scoring system is crucial, for optimal treatment allocation and appropriate information to relatives.
Interventions
- Diagnostic test Calculation of early prognosis score
Early prognosis score will be calculated at intensive care unit admission for each patient based on clinical and biological values as required
Primary outcome measures
- Determination of Area Under Curve of Cerebral Admission Hospital Prognosis (CAHP) Score at intensive care unit admission [Time frame: Intensive Care Unit Admission (Usually 3 hours after cardiac arrest]
Eligibility criteria
Inclusion criteria
- all adult patients, major, admitted to intensive care after cardiac arrest (after both in and out-of hospital cardiac arrest),
- comatose (defined by Glasgow score ≤ 8) on admission,
Exclusion criteria
- cardiac arrest occurring intra-hospital,
- minor patient,
- major patient under guardianship,
- protected persons,
- prior inclusion in the study
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 5 centers
- CHU Nantes — Nantes
- Hopital Jacques Cartier — Massy
- Clinique Ambroise Paré — Neuilly-sur-Seine
- APHP, Cochin — Paris
- CH Versailles — Versailles
Identifiers
NCT: NCT05606809 · 2022-A01811-42