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Recruiting NCT05596474

Effect of Beet-root Juice and PBM Treatments on Muscle Fatigue

No phase Interventional Health Care Utilization Healthy Aging

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Beet-root juice, red-light therapy, Placebo, sham light.
Who it may be relevant to
Registry conditions: Health Care Utilization, Healthy Aging. Basic parameters: from 65 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Application of Beet-root Juice Supplementation and Photobiomodulation Treatment on Forearm Muscle Fatigue in Older Adults

Overview

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question: Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement? Does red light therapy improve forearm muscle endurance compared to a sham light exposure? Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Interventions

  • Dietary supplement Beet-root juice
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.
  • Radiation red-light therapy
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.
  • Dietary supplement Placebo
    Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.
  • Radiation sham light
    Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Primary outcome measures

  • Total forearm work performed [Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes]
Secondary outcome measures (2)
  • Forearm endurance [Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes]
  • Intermuscular coordination [Time frame: During the forearm exercise fatigue protocol lasting up to 45 minutes]

Eligibility criteria

Inclusion criteria

  • Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion criteria

  • Currently smoke
  • Have smoked within the last 6 months
  • Are taking taking supplements known to increase blood nitrate levels
  • Have a known kidney disease
  • Have a known liver disease
  • Have a known thyroid condition
  • Have a known gastritis condition
  • Are taking medications that are known to cause complications with nitrate supplementation
  • Have known or reported joint pain within the dominant hand

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Single blind
Primary purpose
Basic science

Study locations

United States · 1 center
  • Wake Forest Univesity — Winston-Salem

Identifiers

NCT: NCT05596474 · IRB00024675

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗