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Recruiting NCT05574153

Metabolic Risk Factors and Myocardial Oxygenation Reserve

— Observational Metabolic Syndrome

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Cardiac MRI.
Who it may be relevant to
Registry conditions: Metabolic Syndrome. Basic parameters: 18 years — 80 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Canada
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Metabolic Risk Factors and Myocardial Oxygenation Reserve (META-MORE)

Overview

The purpose of this study is to use MRI images using the OS-CMR technique to view the differences in the hearts of healthy volunteers and participants with a condition called Metabolic Syndrome. The objectives of this project are to compare these two groups and to view how health risks, blood test results, and the time since a Metabolic diagnosis can affect heart health.

Detailed description

Myocardial oxygenation changes during vasoactive breathing maneuvers, observed with oxygenation-sensitive cardiac MRI, will be identified and compared between individuals considered healthy and those fitting the criteria of the Metabolic Syndrome.

Interventions

  • Diagnostic test Cardiac MRI
    Participants will undergo an oxygenation-sensitive cardiac MRI and, during the scan, perform a vasoactive breathing maneuver composed of a period of paced hyperventilation followed by a voluntary maximal breath hold.

Primary outcome measures

  • Global and segmental Myocardial oxygenation reserve (MORE) [Time frame: Baseline]
  • Relation between Breathing maneuver induced MORE and known MetS risk factors. [Time frame: Baseline]

Eligibility criteria

Inclusion criteria

Patient Participants:

  • Age 18-80
  • Informed Consent
  • Diagnosis of MetS (through at least 3 MetS characteristics (abdominal obesity, high triglyceride level, low HDL cholesterol, high systolic blood pressure, and high fasting glucose levels)

Healthy Volunteers:

  • Age 18-80
  • No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
  • No Smoking

Exclusion criteria

  • General MRI contraindications\*
  • Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
  • Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Case-control

Study locations

Canada · 1 center
  • The Reseach Institute of the McGill University Health Centre — Montreal

Identifiers

NCT: NCT05574153 · 2021-7267

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗