Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Health Education, Conventional Exercise, Tai Chi.
- Who it may be relevant to
- Registry conditions: Mild Cognitive Impairment. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Hong Kong
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Tai Chi Versus Conventional Exercise to Improve Cognitive Performance in Older Adults With Mild Cognitive Impairment (MCI): A Comparative Randomized Controlled Trial
Overview
This randomized controlled trial aims to evaluate the effectiveness of Tai Chi and conventional exercise on improving cognitive function in older adults with mild cognitive impairment (MCI). Participants will be randomized into three six-month programmes, namely Health Education group, Tai Chi group and Conventional Exercise group. Assessments will be conducted at baseline, after the 26-week interventions, and 26-week after the competition of the intervention.
Interventions
- Behavioral Health Education
A 26 weeks brain health and general health education program with two 1.5-hour sessions weekly. - Behavioral Conventional Exercise
A 26 weeks Conventional Exercise training with two 1.5-hour sessions weekly. - Behavioral Tai Chi
A 26 weeks Tai Chi training with two 1.5-hour sessions weekly.
Primary outcome measures
- The score of the Montreal Cognitive Assessment (MoCA) [Time frame: 26 weeks]
- The score of the Montreal Cognitive Assessment (MoCA) [Time frame: 52 weeks]
Secondary outcome measures (10)
- Clinical Dementia Rating [Time frame: 26 weeks and 52 weeks]
- Neurocognitive Test [Time frame: 26 weeks and 52 weeks]
- Subjective Cognitive Performance [Time frame: 26 weeks and 52 weeks]
- Subjective Memory complaints [Time frame: 26 weeks and 52 weeks]
- Subjective Sleep Quality [Time frame: 26 weeks and 52 weeks]
- The Hospital Anxiety and Depression Scale [Time frame: 26 weeks and 52 weeks]
- The 12-Item Short Form Survey [Time frame: 26 weeks and 52 weeks]
- Medication Use [Time frame: 26 weeks and 52 weeks]
- Short Physical Performance Battery (SPPB) Test [Time frame: 26 weeks and 52 weeks]
- Habitual Physical Activity [Time frame: 26 weeks and 52 weeks]
Eligibility criteria
Inclusion criteria
- Chinese older adults aged equal or larger than 50 years
- Ethnic Chinese
- MCI under criteria of Mayo Clinic, including the following
i. people with subjective complaint about a decline in cognitive function. ii. total score in the Montreal Cognitive Assessment is equal or below the 7th percentile of the age- and education- corrected normative data of Hong Kong. iii. the decline in cognitive function does not impair daily functioning, as revealed by getting ≥2 marks in every item on the Chinese Lawton Instrumental Activities of Daily Living 4-point Scale).
Exclusion criteria
- medical history of major chronic diseases such as cancer, stroke, cerebro- and cardio-vascular diseases, and renal disease
- uncontrolled diabetes
- diagnosed with dementia or using anti-dementia medication
- diagnosed with psychiatric diseases or using psychiatric medication
- with diseases or on medications known to severely affect cognitive performance
- somatic condition (e.g., limb lost) that prevent participation in exercise
- impaired mobility by chronic diseases (e.g., neurological, musculoskeletal and autoimmune diseases)
- incapable to perform physical exercise
- regular exercise habit (>3 times 60-min Tai Chi or moderate-intensity conventional exercise weekly) in the past 3 months
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
Hong Kong · 1 center
- The University of Hong Kong — Hong Kong
Identifiers
NCT: NCT05540613 · TC_MCI_RCT