Enhancing Innate Anti-Viral Resistance Through A Community-Based Intervention - Generation Xchange
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: GenX intergenerational mentoring program.
- Who it may be relevant to
- Registry conditions: Virus Infection, RNA. Basic parameters: from 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This randomized controlled trial will test whether a recently developed community-based intergenerational mentoring program known as Generation Xchange (GenX) can enhance antiviral resistance in older African-American women and men in a low-SES urban community. Additional studies will identify the biological processes that promote resistance to respiratory virus infections and viral disease in older African-American women and men.
Detailed description
This randomized controlled intervention trial (planned n=160) will test whether participation in the Generation Xchange (GenX) intergenerational mentoring program can reduces vulnerability to respiratory virus infections (COVID, influenzas, colds), increase antiviral immune activity (Type I interferon responses), and reduce inflammatory immune activity in older African-American women and men living in a socioeconomically disadvantaged urban community. Blood samples will also be collected to determine which biological factors are most important in protecting older African-Americans from respiratory virus infection, and which of those factors is affected by the GenX intervention.
Interventions
- Behavioral GenX intergenerational mentoring program
GenX trains older adults to collaborate with K-3rd grade teachers in mentoring high-need elementary school students in core reading and math skills.
Primary outcome measures
- Concentration of Type I interferon antiviral activity (bioassay International Units / mL) [Time frame: 10 months]
Secondary outcome measures (2)
- Respiratory virus antibody concentration (WHO international units BAU/mL) [Time frame: 10 months]
- Pro-inflammatory cytokine concentration (pg/mL) [Time frame: 10 months]
Eligibility criteria
Inclusion criteria
- Participating in the GenX intergenerational mentoring program
- All GenX mentors > 50 years of age are eligible to participate in this research
- GenX program participation requires:
- Reside in neighborhood of GenX schools (South-Central Los Angeles)
- Pass basic literacy and cognitive function tests
Exclusion criteria
- Any health condition that would put participant at risk by enrollment/participation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- UCLA School of Medicine — Los Angeles
Publications
- Seeman T, Merkin SS, Goldwater D, Cole SW. Intergenerational mentoring, eudaimonic well-being and gene regulation in older adults: A pilot study. Psychoneuroendocrinology. 2020 Jan;111:104468. doi: 10.1016/j.psyneuen.2019.104468. Epub 2019 Sep 27. PMID 31589939
Identifiers
NCT: NCT05534425 · 21-001388 · R01AG073053