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Recruiting NCT05522972

Establishing New Treatment Approaches for Amblyopia: Perceptual Learning and Video Games

No phase Interventional Amblyopia

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: Video Game Vision Training, Perceptual Learning, Occlusion Therapy.
Who it may be relevant to
Registry conditions: Amblyopia. Basic parameters: No limits · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Improving Normal and Amblyopic Vision With Video Games and Perceptual Learning

Overview

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Detailed description

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. Our previous findings (see Publications) show that the adult amblyopic brain is still plastic and malleable, suggesting that active approach is potential useful in treating amblyopia.The goal of this project is to assess the limits and mechanisms of neural plasticity in both normal and amblyopic spatial vision. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia. Research participants will be asked to practice a visual discrimination task (perceptual learning) or to play video games with the amblyopic eye for a period of time. A range of visual functions will be monitored during the course of treatment.

Interventions

  • Behavioral Video Game Vision Training
    A new approach for improving amblyopic vision using video games
  • Behavioral Perceptual Learning
    A new approach for improving amblyopic vision with perceptual learning
  • Behavioral Occlusion Therapy
    Conventional treatment for amblyopia

Primary outcome measures

  • Change in visual acuity before and after the intervention [Time frame: 9 months]
  • Change in stereoacuity before and after the intervention [Time frame: 9 months]
Secondary outcome measures (2)
  • Change in contrast sensitivity before and after the intervention [Time frame: 9 months]
  • Change in positional (or Vernier) acuity before and after the intervention [Time frame: 9 months]

Eligibility criteria

Inclusion criteria

  • adults and children with normal vision or amblyopia
  • amblyopia: interocular VA difference of 0.1 logMAR or more

Exclusion criteria

  • any ocular pathological conditions, nystagmus

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Crossover
Masking
Open label
Primary purpose
Treatment

Study locations

United States · 1 center
  • Nova Southeastern University College of Optometry — Fort Lauderdale

Publications

  • Li RW, Li BZ, Chat SW, Patel SS, Chung STL, Levi DM. Playing three-dimensional video games boosts stereo vision. Curr Biol. 2024 Jun 3;34(11):R524-R525. doi: 10.1016/j.cub.2024.04.032. PMID 38834021
  • Leung TW, Li RW, Kee CS. Brief Adaptation to Astigmatism Reduces Meridional Anisotropy in Contrast Sensitivity. Invest Ophthalmol Vis Sci. 2023 Sep 1;64(12):4. doi: 10.1167/iovs.64.12.4. PMID 37656478
  • Li RW, Levi DM. Characterizing the mechanisms of improvement for position discrimination in adult amblyopia. J Vis. 2004 Jun 1;4(6):476-87. doi: 10.1167/4.6.7. PMID 15330715
  • Li RW, Klein SA, Levi DM. Prolonged perceptual learning of positional acuity in adult amblyopia: perceptual template retuning dynamics. J Neurosci. 2008 Dec 24;28(52):14223-9. doi: 10.1523/JNEUROSCI.4271-08.2008. PMID 19109504
  • Li RW, Provost A, Levi DM. Extended perceptual learning results in substantial recovery of positional acuity and visual acuity in juvenile amblyopia. Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5046-51. doi: 10.1167/iovs.07-0324. PMID 17962456
  • Li RW, Young KG, Hoenig P, Levi DM. Perceptual learning improves visual performance in juvenile amblyopia. Invest Ophthalmol Vis Sci. 2005 Sep;46(9):3161-8. doi: 10.1167/iovs.05-0286. PMID 16123415
  • Li RW, Ngo CV, Levi DM. Relieving the attentional blink in the amblyopic brain with video games. Sci Rep. 2015 Feb 26;5:8483. doi: 10.1038/srep08483. PMID 25715870
  • Li RW, Ngo C, Nguyen J, Levi DM. Video-game play induces plasticity in the visual system of adults with amblyopia. PLoS Biol. 2011 Aug;9(8):e1001135. doi: 10.1371/journal.pbio.1001135. Epub 2011 Aug 30. PMID 21912514

Identifiers

NCT: NCT05522972 · 2022-344

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗