Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Step 1 - Screening ; Step 2 - Clinical interview.
- Who it may be relevant to
- Registry conditions: Autism Spectrum Disorder, Siblings, Neurodevelopmental Disorders. Basic parameters: 2 years — 16 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure.
Detailed description
Although NDD are frequent among siblings of children with ASD, their developmental screening is not yet sufficiently organized in routine practice. The needs and the characteristics of these siblings have yet to be better understood in order to define their developmental surveillance.
Interventions
- Diagnostic test Step 1 - Screening ; Step 2 - Clinical interview
Step 1: screening is performed by online parental questionnaires (SRS-2, Identidys scale, DCDQ, parental concerns questionnaire ) via a web platform. Parents and registered doctors will be informed by mail in case of negative screening; In case of positive screening, they will be called by phone in order to give them the results and to invite them for a clinical and semi-structured interview. Step 2: The semi-structured interview will be performed by a psychologist specialized in NDD in order t
Primary outcome measures
- Percentage of family participation [Time frame: 12 months]
Secondary outcome measures (2)
- Sensibility, specificity, positive predictive values (PPV) and negative predictive values (NPV) of the screening procedure [Time frame: 12 months]
- Percentage of satisfied parents [Time frame: 12 months]
Eligibility criteria
Inclusion criteria
- Step 1: Brothers or sisters (including stepsisters and brothers); aged between 2 and 16 years; living in Occitanie; informed and express consent of parents ; affiliated to social security.
- Step 2: step 1 positive screening or parental concerns for child's development ; parental signed informed consent.
Exclusion criteria
- Parents (or child) refusal to participate; adopted brother or sister. Do not speak French
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- Chu Montpellier — Montpellier
Publications
- Baghdadli A, Audras-Torrent L, Rattaz C, Gonnier V, Ferrando L, Michelon C, Odoyer R, Maffre T, Picot MC. Multistage screening process for neurodevelopmental disorders in siblings of children with autism: the FRATSA protocol study. BMJ Open. 2023 Jan 30;13(1):e066520. doi: 10.1136/bmjopen-2022-066520. PMID 36717133
Identifiers
NCT: NCT05512637 · RECHMPL21_0358