Neuromodulation and Fatigue
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: electrical stimulation.
- Who it may be relevant to
- Registry conditions: Healthy Aging, Fatigue. Basic parameters: 18 years — 50 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Neuromodulation and Its Effects on Muscle Activity and Fatigue
Overview
In this project, we aim to determine any potential effects of a weak electrical current applied to the neck or thoracic area on functional capacity and muscle activation. Healthy individuals will participate in one familiarization followed by up to 6 experimental sessions. Fatigability and motor function will be assessed in each test session.
Detailed description
This project will investigate the potential impact of an electrical current of low intensity, and applied non-invasively, on the signals that drive muscle contractions. Individuals will receive distinct types of stimulation that vary depending on the direction on the current (anodal vs cathodal) and placement of the electrodes. These conditions will be compared to a sham stimulation. The test session will be randomized in a double blind fashion, which indicates that neither participants or investigators will know the type of stimulation. Motor function and the muscle electrical activity will be quantified during each test session.
Interventions
- Behavioral electrical stimulation
different types of low-intensity (comfortable) electrical stimulation will be used and applied in distinct locations
Primary outcome measures
- Force [Time frame: Each session will take approximately 2 hours (total of 4 test sessions)]
- Perception of effort [Time frame: Each session will take approximately 2 hours (total of 4 test sessions)]
- Muscle activation [Time frame: Each session will take approximately 2 hours (total of 4 test sessions)]
Eligibility criteria
Inclusion criteria
Healthy individuals between 18 and 50 years old
Exclusion criteria
Metal implants or joint replacement. Presence of neuromuscular disease. Skin hypersensitivity.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Single group
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Oklahoma — Norman
Identifiers
NCT: NCT05487131 · 14921P