The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: removal of exercise.
- Who it may be relevant to
- Registry conditions: Glucose Intolerance, Exercise, Vascular Function. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The Impact of Removal of Exercise on Glycemic Control and Vascular Health in Older Active
Overview
The purpose of this study is to determine if an acute bout of removal of exercise reduces enothelial function and glycemic control in an active, older adult population; and whether a 3 day return to exercise restores this response. Glycemic control is the blood glucose response following the consumption of a meal. It is an indicator of insulin resistance (or type 2 diabetes) and impaired glycemic control has been suggested to lead to cardiovascular disease. Endothelial function has been shown to be improved by chronic or acute increases in physical activity. Both of these have been shown to be impaired to acute bouts of inactivity in young populations; however the impact of acute inactivity in older adults is less understood. In this proposal the investigators will examine 1)how quickly impairments in glycemic control occur to acute physical inactivity in older adults who exercise, 2) how quickly impairments in endothelial function occur to acute inactivity in older adults who exercise, and 3) whether 3 days of a return to exercise restores these responses.
Interventions
- Other removal of exercise
Subjects will stop doing their normal exercise routines for 3 or 5 days and then subjects will resume doing their normal exercise routines for 3 days.
Primary outcome measures
- Continuous glucose monitoring [Time frame: 3 days before removal of exercise]
- Continuous glucose monitoring [Time frame: After removal of exercise for 5 days]
- Continuous glucose monitoring [Time frame: After return to exercise for 3 days]
- Flow mediated dilation [Time frame: 3 days before removal of exercise]
- Flow mediated dilation (vascular health) [Time frame: After removal of exercise for 5 days]
- Flow mediated dilation (vascular health) [Time frame: After return to exercise for 3 days]
Eligibility criteria
Inclusion criteria
- 55 years and older, 18-40 years old
- Healthy, physically active, performing at least 90 min/week of physical activity
- Free of physical limitations that may interfere with alterations in daily physical activity levels
Exclusion criteria
- Physician diagnosed HIV, hepatitis, or tuberculosis.
- Body weight change of greater than 5% within the previous 2 months
- Smoking within the previous 2 months.
- Taking medications that alter blood glucose levels
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- Old Dominion University — Norfolk
Identifiers
NCT: NCT05468255 · AGEGLYFMD