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Recruiting NCT05454267

Early Detection of Vaping-related Vascular Diseases

Observational Vaping Blood Vessel Injury

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Vaping, Blood Vessel Injury. Basic parameters: 18 years — 40 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Overview

The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.

Primary outcome measures

  • Airway blood flow reactivity (QAW) [Time frame: Up to 1 week]
  • Pulmonary vascular resistance (PVR) [Time frame: Up to 4 weeks]
  • Flow-mediated vasodilation (FMD) [Time frame: Up to 4 weeks]

Eligibility criteria

Inclusion criteria

Vapers Group:

  • Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods.
  • Adults aged 18-40 years

Healthy Group:

  • Healthy never smokers, never vapers
  • Adults aged 18-40 years

Exclusion criteria

  • Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study.
  • Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI>40 kg/m2), hypertension or diabetes
  • Pregnant or breastfeeding women

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Observational model
Other

Study locations

United States · 1 center
  • University of Miami Health System — Miami

Identifiers

NCT: NCT05454267 · 20211060

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗