Role of the Immune Environment in Response to Therapy in Breast Cancer
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Collection of personal health information from women treated at the University of Pennsylvania under an approved HIPAA waiver..
- Who it may be relevant to
- Registry conditions: Breast Cancer, ER Positive Breast Cancer, HER2-negative Breast Cancer, TNBC - Triple-Negative Breast Cancer. Basic parameters: from 18 years · Female.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
This is an observational case-control study of tissues collected from women with ER+HER2- breast cancers. The immune environments of these cancers will be compared to triple negative and HER2+ breast cancers. No randomization or changes to standard of care treatment will occur as part of the study.
Interventions
- Other Collection of personal health information from women treated at the University of Pennsylvania under an approved HIPAA waiver.
Collection of personal health information from women treated at the University of Pennsylvania under an approved HIPAA waiver.
Primary outcome measures
- Collecting, processing and archiving breast cancer tumor tissues [Time frame: Through study completion, average of 2 years]
Secondary outcome measures (1)
- Associating breast cancer dendritic cell infiltrate with outcome [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
Women 18 years of age or older with non-metastatic breast cancer undergoing surgical resection in the University of Pennsylvania Health System.
Exclusion criteria
Males Children Pregnant individuals
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- Abramson Cancer Center — Philadelphia
Identifiers
NCT: NCT05396612 · UPCC 19121 · 850338