Effect of Phlebotomy on Heartrate in Polycythemia Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: phlebotomy.
- Who it may be relevant to
- Registry conditions: Polycythemia. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Netherlands
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Phlebotomy in Blood Donors and Polycythemia Vera Patients- The Effect on Physiology: An Orienting Case-Cross Over Study
Overview
Single-centre, observational within-subject design: patients that undergo phlebotomies regularly for polycythemia will be measured continuously by wearables one week before until one week after a phlebotomy, for three phlebotomies.
Detailed description
Rationale: Little is known about the effect of a hemoglobin-shift on patients, anaemic, non-anaemic or even polycythaemic. It has been established that severe anaemia has deteriorating effects on the patient, which can be (partially) reversed by treatments like transfusion, erythropoietin stimulating agents or iron/vitamin supplements, depending of the etiology of the anaemia. However, the optimal haemoglobin target and threshold for such treatments has yet to be determined. It is therefore necessary to evaluate what the exact effect of various haemoglobin levels, and a shift therein, is on the physiology of patients. Only then can the benefits be weighed properly against the risks for individual patients when considering treatment for anaemia, safety of blood donation, or expected effect of phlebotomy for polycythaemia.
Primary Objective:
\- Compare the per individual and per group effects of a reduction in Hb mass on physical functional outcomes (heart rate; activity parameters; QoL) in patients with polycythaemia.
Secondary Objectives:
\- Compare the primary outcomes to data from the REMOTE-2 and FAINT-study (similar measurements in transfusion dependent patients and whole blood donors)
Study design: Within-subject design. Patients will be remotely monitored one week before phlebotomy until one week after.
Study population: Adult patients with a polycythaemia requiring phlebotomies on a regular basis.
Main study parameters: heart rate, blood pressure, activity parameters and quality of life.
Interventions
- Procedure phlebotomy
500ml of blood phlebotomized per standard of care to reduce symptoms from polycythemia
Primary outcome measures
- Mean heart rate as measured by the withings BPM and withings Steel HR biodevices [Time frame: one week before until one week after phlebotomy; for three phlebotomies]
Secondary outcome measures (3)
- Systolic and diastolic blood pressure as measured by the withings BPM connect. [Time frame: Daily basis from one week before until one week after phlebotomy; three phlebotomies]
- Number of steps per 24hrs as measured by the withings steel HR [Time frame: one week before until one week after phlebotomy; for three phlebotomies]
- Quality of life as measured by the EuroQol-5D questionnaire (EQ5D) [Time frame: Daily basis from one week before until one week after phlebotomy; three phlebotomies]
Eligibility criteria
Inclusion criteria
- Patients with polycythaemia, requiring phlebotomy on a regular basis (at least every 4 months)
- Subjects aged ≥18 years
- In possession of a smartphone
- Life expectancy ≥ 3 months
Exclusion criteria
- Poor performance/functional status (Eastern Cooperative Oncology Group system ECOG ≥3)
- Participants with known arrhythmias or other significant cardiological conductivity disorders (Paroxysmal atrial fibrillation is allowed)
- Hospitalized subjects
- Subjects with a pacemaker.
- Subjects with a secondary polyglobulia due to eg smoking or other pulmonary issues.
- Scheduled oncological treatments or surgery during the study period.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Netherlands · 1 center
- LUMC — Leiden
Identifiers
NCT: NCT05396170 · N22.055