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Recruiting NCT05384158

Valuation in Depressed Mood, Anhedonia, and Anxiety

No phase Interventional Neurobehavioral Components of Reward and Loss Valuation

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: cognitive behavioral therapy, valuation with instruction, valuation without instruction.
Who it may be relevant to
Registry conditions: Neurobehavioral Components of Reward and Loss Valuation. Basic parameters: 25 years — 50 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
United States
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Overview

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Detailed description

This study tests relationships among neural and behavioral valuation mechanisms, and how these mechanisms change (or not) over time, with task instructions, and following cognitive behavior therapy.

Interventions

  • Behavioral cognitive behavioral therapy
    cognitive behavioral therapy
  • Behavioral valuation with instruction
    repeat laboratory sessions of computerized learning game
  • Behavioral valuation without instruction
    repeat laboratory sessions of computerized learning game

Primary outcome measures

  • change in proportion correct on the 'N-arm bandit learning task' [Time frame: study entrance to study exit, an average of 12 weeks]
Secondary outcome measures (3)
  • change in depression symptoms (Beck Depression Inventory) [Time frame: study entrance to exit, an average of 12 weeks]
  • change in anxiety symptoms (anxiety subscale; Mood and Anxiety Symptom Questionnaire) [Time frame: study entrance to exit, an average of 12 weeks]
  • change in anhedonia symptoms (anhedonia subscale; Mood and Anxiety Symptom Questionnaire) [Time frame: study entrance to exit, an average of 12 weeks]

Eligibility criteria

Inclusion criteria

  • mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games.

Exclusion criteria

  • history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Open label
Primary purpose
Basic science

Study locations

United States · 1 center
  • Fralin Biomedical Research Institute at Virginia Tech Carilion — Roanoke

Identifiers

NCT: NCT05384158 · RDOC

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗