Recruiting NCT05357768
Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue.
- Who it may be relevant to
- Registry conditions: Undifferentiated Round Cell Sarcoma. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Italy
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Experimental study with biological material : case series review of clinical and histological data
Detailed description
This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.
Interventions
- Other data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue
Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.
Primary outcome measures
- event free survival [Time frame: baseline]
Eligibility criteria
Inclusion criteria
- Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included.
- Clinical and outcome information available.
- Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available.
Exclusion criteria
- Diagnosis different from undifferentiated round cell sarcomas
- Patient with no clinical or outcome information available
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Other
Study locations
Italy · 1 center
- IRCCs Istituto Ortopedico Rizzoli — Bologna
Identifiers
NCT: NCT05357768 · GRACefUl