Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: blood sample.
- Who it may be relevant to
- Registry conditions: Chronic Thromboembolic Pulmonary Hypertension. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Proteomic Pattern Associated With the Diagnosis of Chronic Thromboembolic Pulmonary Hypertension : PROTEO-CTEPH Study.
Overview
Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH) is a rare but severe complication of pulmonary embolism (PE). CTEPH is evoked in patients with persistent dyspnea. According to international guidelines, symptomatic patients with perfusion defects on lung scan and Pulmonary Hypertension (PH)-likely transthoracic echo (TTE) must be evaluated in Pulmonary Hypertension (PH)-centers with right heart catheterism, to confirm or rule out the presence of precapillary Pulmonary Hypertension (PH), and precise the group of Pulmonary Hypertension (PH).
Detailed description
However, persistent dyspnea and perfusion defects are frequent after pulmonary embolism (PE), and the accuracy of transthoracic echo (TTE) is not great for precapillary Pulmonary Hypertension (PH).
This study proposed to seek for a specific proteomic pattern in patients admitted for a suspicion of Chronic ThromboEmbolic Pulmonary Hypertension (CTEPH).
Interventions
- Biological blood sample
to realize proteomic analysis.
Primary outcome measures
- Proteomic pattern associated with the diagnosis of Chronic thromboembolic pulmonary hypertension (CTEPH) [Time frame: Day: 0]
Secondary outcome measures (7)
- Analysis of recording of hemodynamic data at diagnosis [Time frame: Day: 0]
- Analysis of recording of hemodynamic data at diagnosis [Time frame: Day: 0]
- Analysis of recording of hemodynamic data at diagnosis [Time frame: Day: 0]
- Analysis of recording of hemodynamic data at diagnosis [Time frame: Day: 0]
- Analysis of recording of hemodynamic after 6 months of treatment [Time frame: 6 months]
- Analysis of recording of hemodynamic after 6 months of treatment [Time frame: 6 months]
- Analysis of recording of hemodynamic data at diagnosis and at death [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Patient with a suspicion of Chronic thromboembolic pulmonary hypertension (CTEPH) with a combination of a perfusion lung scan and transthoracic perfusion scan and transthoracic echocardiography compatible with the diagnosis (according to French recommendations)
- Patients who require a right heart catheterization.
- Patient affiliated or entitled to a social security plan
- Patient having received informed information about the study informed about the study
Exclusion criteria
- Patient with a normal perfusion lung scan
- Person under legal guardianship
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHU de SAINT-ETIENNE — Saint-Etienne
Identifiers
NCT: NCT05340023 · 21CH115 · ANSM