Local and Systemic Changes in Osteonecrosis of the Jawbone
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Osteonecrosis of the Jaw. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Austria
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Pilot Study: Local and Systemic Changes in Osteonecrosis of the Jawbone
Overview
Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.
Primary outcome measures
- target gene expression [Time frame: through study completion, an average of 1 year]
Eligibility criteria
Inclusion criteria
- 18 years or older
- with/without ART
- with/without MRONJ
Exclusion criteria
- smoker (>10 cigarettes/day)
- pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
Austria · 1 center
- Medical University of Graz — Graz
Identifiers
NCT: NCT05329558 · 30-196 ex 17/18