Improvement in Glycemic Response After Bariatric Surgery
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: sleeve gastrectomy surgery, gastric bypass surgery, control, Pancreatectomy.
- Who it may be relevant to
- Registry conditions: Bariatric Surgery. Basic parameters: 18 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Israel
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
decipher the role of microbiota in glycemic response change after bariatric surgery
Detailed description
Despite the vast knowledge linking the gut microbiome to metabolism and the glucose response, the relation still remains unclear. hopefully, a deep understanding of the mechanisms underlying metabolic improvement following bariatric surgery will make it possible to identify targets for pharmacological intervention, which will reduce the need for surgery and its risks.
Previous studies have characterized the microbiome after bariatric surgery, but most suffer from methodological limitations.
The current study has the potential to be innovative and make a significant contribution to understanding the mechanisms involved in early metabolic improvement after bariatric surgery.
Interventions
- Procedure sleeve gastrectomy surgery
participants undergoing sleeve gastrectomy surgery - Procedure gastric bypass surgery
participants undergoing gastric bypass surgery - Procedure control
cholecystectomy - Procedure Pancreatectomy
Collecting a sample of an unidentified healthy pancreas to extract insulin-secreting beta cells from the sample
Primary outcome measures
- Glycemic response [Time frame: up to 4 years]
- microbiota composition [Time frame: up to 4 years]
Eligibility criteria
Inclusion criteria
- candidates of bariatric surgery or cholecystectomy
- age 18-70
- male/female
Exclusion criteria
- previous bariatric surgery
- type 1 diabetes
- antibiotic treatment 3 months prior to the study
- probiotic treatment 3 months prior to the study
- chronic disease - gastrointestinal disease, malignancy, psychiatric disorder, endocrinologic disorders
- any pathologic findings during endoscopy
- participants who will suffer from a post-operation complication
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Israel · 2 centers
- Weizmann Institute of Science — Rehovot
- Souraski medical center — Tel Aviv
Identifiers
NCT: NCT05325736 · 0046-21-TLV