The Dampness Syndrome of Chinese Medicine Cohort Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: natural aging process.
- Who it may be relevant to
- Registry conditions: Chronic Disease, Cancer, Dementia Alzheimers, Metabolic Disease. Basic parameters: 35 years — 79 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
A Multi-Center Prospective Cohort Study of Dampness Syndrome in China
Overview
The researchers plain to build a large-scale, longitudinal, prospective cohort characterized by TCM dampness syndrome. With the biobank of this cohort the investigators want to find the causality between TCM dampness syndrome and clinical chronic diseases and a new way to treat clinical disease.
Detailed description
DACOS is a national large- scale, longitudinal, multi-center, prospective, cohort study of natural person aged 35 to 75. The baseline survey and the follow-up surveys will be conducted in 5 areas covering the eastern, northern, western, southern and middle parts of China. In this study 100,000 natural person will be regularly followed up for 5 years(visited once a year), with the loss rate ≤15%. Three parts will be carried in the form of interview, physical examination and biological sample collection. During the interview, the investigators plan to do some questionnaires to learn participants' demographic characteristics, life style, disease history, healthy condition(EQ-5D-5L, SDS,), cognition state(AD-8, MMSE, MoCA) and the results of TCM syndrome differentiation(Score of Dampness syndrome and TCM constitution scale). All biological specimens (including blood, feces, urine, saliva and tongue coating) will be collected and stored in the biological resource center until researchers request their use. With the building up of this cohort, the researchers will analyze the causality between dampness syndrome and specific chronic diseases such as diabetes, coronary heart disease, cancer, dementia and so on.
Interventions
- Other natural aging process
To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.
Primary outcome measures
- emerging diseases [Time frame: through study completion, an average of 1 year]
Secondary outcome measures (12)
- Montreal Cognitive Assessment(MoCA) [Time frame: through study completion, an average of 1 year]
- European Quality of Life 5-dimensional questionnaire (EQ-5D-5L) [Time frame: through study completion, an average of 1 year]
- Mini-Mental State Exam (MMSE) [Time frame: through study completion, an average of 1 year]
- interview questionnaire [Time frame: through study completion, an average of 1 year]
- change of the blood routine results [Time frame: through study completion, an average of 1 year]
- urine routine [Time frame: through study completion, an average of 1 year]
- change of faeces routine [Time frame: through study completion, an average of 1 year]
- change of hepatic function [Time frame: an average of 1 year]
- change of renal function [Time frame: an average of 1 year]
- change of CRP [Time frame: an average of 1 year]
- change of Hcy [Time frame: an average of 1 year]
- change of thyroid function [Time frame: an average of 1 year]
Eligibility criteria
Inclusion criteria
- Residents aged 30 to 79, whose residence is consistent with their registered permanent residence location;
- Residents who voluntarily participate in the project, agree to the collection of their biological information, and sign the informed consent form;
- Residents who have no mental illness and other related diseases, and display a normal ability of expression and understanding;
Exclusion criteria
- Residents who reject collaboration;
- Residents who allow no follow-up visits.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
China · 1 center
- Guangdong Province Hospital of Tradtional Chinese Medicine — Guangzhou
Publications
- Li M, Liu N, Jiang G, Zeng H, Guo J, Wu D, Zhou H, Wen Z, Zhou L. Health-related quality of life in populations with diabetes, prediabetes, and normal glycemic levels in Guangzhou, China: a cross-sectional study. Front Endocrinol (Lausanne). 2025 May 23;16:1518204. doi: 10.3389/fendo.2025.1518204. eCollection 2025. PMID 40487765
Identifiers
NCT: NCT05315895 · SZ2021ZZ06