Brain Activity in Epilepsy
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: macro/micro electrode recording.
- Who it may be relevant to
- Registry conditions: Epilepsy. Basic parameters: 18 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Study of Brain Activity in Candidates for Epilepsy Surgery
Overview
Prospective interventional study with implantation of micro-electrodes to study the brain networks in epilepsy at high spatiotemporal resolution.
Detailed description
The goal of this trial is to study brain activity in epilepsy at high spatiotemporal resolution. Apart from the epileptogenic network (dysfunctional areas), the investigators will study human brain function.
The use of micro-electrode arrays allows to study the human brain a high spatiotemporal resolution, even at the single neuron level.
Scientific objectives of the current project:
* To record neural signals from macro-electrodes and delineate the epileptogenic network and study brain function during specific tasks. * To record neural signals from micro-electrodes and delineate the epileptogenic network and study brain function during specific tasks. * Identifying pivotal regions for BMI applications and developing online decoding algorithms. * Comparing neural recordings to fMRI activity
Interventions
- Device macro/micro electrode recording
intracranial macro/micro-electrode placement at the cerebral cortex or in deeper brain areas with te use of macro/micro electrode recording. Macro/micro electrodes are placed at the cerebral cortex or in deeper brain areas in order to precisely identify the epileptogenic focus
Primary outcome measures
- Electrophysiological recordings: single neuron recordings [Time frame: 15 years]
- Electrophysiological recordings: LFP [Time frame: 15 years]
- fMRI recordings [Time frame: 15 years]
Secondary outcome measures (3)
- Neurophysiological study of different brain areas: power gamma band [Time frame: 15 years]
- Neurophysiological study of different brain areas: spike activity [Time frame: 15 years]
- Neurophysiological study of different brain areas: fMRI [Time frame: 15 years]
Eligibility criteria
Inclusion criteria
- Age ≥18 yo
- Epilepsy patients undergoing intracranial electrode placement.
- Able to understand the procedure involved and to consent.
Exclusion criteria
- Age < 18 yo
- Pregnancy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
Belgium · 1 center
- UZ Leuven — Leuven
Identifiers
NCT: NCT05307146 · S53126