Investigating Myocardial Remodelling in the Failing Human Heart
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Heart Failure. Basic parameters: 18 years — 100 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Norway
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Despite improvements in therapy, heart failure is a disease with high mortality and accelerating prevalence. To improve patient care, it is necessary to better understand the features and underlying mechanisms of myocardial remodeling; how it manifests in vivo and its underlying cellular and extracellular changes. The RELAX study will offer insight into myocardial remodeling, by comprehensively assessing function and structure of failing human hearts, and investigate its underlying cellular and extracellular changes.
Primary outcome measures
- MRI functional parameters including Left Ventricular Ejection Fraction and Global Longitudinal Strain [Time frame: 1 years]
- MRI morphological parameters including LVEDV and LVESV. [Time frame: 1 years]
- Myocardial stiffness measured by MRI and ex-vivo methods. [Time frame: 1 year]
Eligibility criteria
Inclusion criteria
- Eligible for heart transplantation
- Willingness to participate in the present study and ability to understand and sign the written informed consent
Exclusion criteria
- Patients under the age of 18.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-only
Study locations
Norway · 1 center
- Oslo University Hospital — Oslo
Identifiers
NCT: NCT05303896 · 230524