Secretin in Refeeding
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Anorexia in Adolescence. Basic parameters: 13 years — 24 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Secretin Levels in Refeeding-induced Polyuria (Cross Section)
Overview
Patients with restrictive-type anorexia nervosa who are admitted to the hospital for feeding often urinate excessive amounts. Others have changes in the way that they handle acid and base. These issues prolong hospitalizations. Current data suggest that one hormone--named secretin--may control both urine output and how the body handles acid and base. This study will evaluate whether secretin levels are different in anorexic patients who urinate an excessive amount compared to those who urinate normal amounts. For this study, patients will have one extra blood draw before and after one meal during their hospitalization. The blood draw before the meal coincides with a standard of care blood draw. Also after the meal, subjects will be asked to provide one extra urine sample. Information from subject's medical records will also be used.
Primary outcome measures
- Change in secretin [Time frame: 1 hour]
Secondary outcome measures (1)
- Change in serum bicarbonate [Time frame: 1 hour]
Eligibility criteria
Inclusion criteria
- Group 1:
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- >4 cc/kg/day of urine output (a.k.a. "fluid dumpers"; n=5)
- Group 2:
- male and female patients
- age 13-24 years
- diagnosis of restrictive-type anorexia nervosa
- hospitalization for nutritional support
- <2 cc/kg/d of urine output (a.k.a. "non-dumpers"; n=5)
Exclusion criteria
- 5150 hold
- Anti-depressant, anti-psychotic, or anticonvulsant medications
- Previous hospitalization within the past 6 months
- Underlying metabolic disorder not related to anorexia nervosa (including chronic kidney disease, renal tubular disorders, and underlying endocrine disorders)
- Pregnancy
- NG or G-tube feeds after day 2 of hospitalization
- > 10% of nutritional needs from supplemental feeds
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
United States · 1 center
- University of California, Los Angeles (UCLA) — Los Angeles
Identifiers
NCT: NCT05235867 · IRB#21-001489