Perturbation Training Reduces Falls in People With Alzheimer's Disease (AD)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Perturbation training.
- Who it may be relevant to
- Registry conditions: Alzheimer Disease. Basic parameters: 65 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Motor Learning of Fall Resistant Skills From Laboratory-induced Falling Among People With Mild Alzheimer's Disease
Overview
This study will examine the overall capacity of people with Alzheimer's disease learning fall-resistant skills from perturbation training.
Detailed description
Falls can cause injury and death in older adults. Those with Alzheimer's disease are at an even higher fall risk. Our goal is to test if people with mild Alzheimer's disease can learn fall prevention skills from the exposure to large-scale perturbations on a treadmill. Two groups with mild Alzheimer's disease will be enrolled. One group will attend a perturbation training session while the other group receives no training. Groups will then be exposed to perturbations on the ground immediately and three or six months after the training. Over six months after the training, daily-living falls will be tracked for both groups. The falls following the perturbations in the lab and daily-living all-cause falls will be compared between groups to test our specific aims: 1) to test if people with Alzheimer's disease can adapt to large-scale external perturbations and learn fall resistant motor skills; 2) to inspect whether people with Alzheimer's disease can retain motor skills learned in Aim 1; and 3) to determine if people with Alzheimer's disease can generalize fall resistant skills to different contexts (treadmill to overground, inside the lab to outside the lab).
Interventions
- Behavioral Perturbation training
Participants will experience repeated perturbations mixed with non-perturbed trials on the treadmill with the protection by a harness.
Primary outcome measures
- Lab-induced faller rate [Time frame: 6 months]
Secondary outcome measures (2)
- Dynamic stability [Time frame: 6 months]
- Number of prospective fall incident [Time frame: 6 months]
Eligibility criteria
Inclusion criteria
- Participants must be at least 65 years old;
- Participants have a clinical diagnosis of probable AD;
- Participants can read and understand English;
- Participants must be able to walk independently at least 25 feet;
- Participants must be able to stand independently for at least 30 seconds;
- Participants must have a Montreal Cognitive Assessment score of 11-21 or Mini Mental Status Examination score between 18 and 23.
Exclusion criteria
- Individuals have ever experienced perturbation training;
- Individuals have hypotension or uncontrolled hypertension;
- Individuals exhibit osteoporosis;
- Participants suffer from coexisting psychiatric disorders, or other neurological conditions, or injuries, etc.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Single blind
- Primary purpose
- Prevention
Study locations
United States · 1 center
- Reminiscent — Valdosta
Identifiers
NCT: NCT05205980 · H22487