Effect of Acute Nitrate Supplementation on Vascular Function in Hispanic, Black and White Population
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Beetroot juice, Placebo drink.
- Who it may be relevant to
- Registry conditions: Healthy Adults. Basic parameters: 18 years — 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of the study is to assess vascular function in African Americans, Hispanic and Caucasian Americans to better understand racial differences in cardiovascular health. The investigators will further investigate the affect of Beetroot juice on the vascular function of all participants.
Detailed description
African Americans and Hispanic individuals have the highest incidence of type 2 diabetes, which increases their risk of all cardiovascular diseases. One of the hallmarks of type 2 diabetes is vascular dysfunction, caused by a lack of nitric oxide bioavailability. Vascular function and blood flow responses to exercise have been shown to improve after nitrate supplementation (beetroot juice), However, whether nitrate supplementation will improve vascular function in African American and Hispanic individuals remains unknown. The investigators will perform a randomized, placebo-controlled study in healthy African American, Hispanic and Caucasian subjects. They will be studied before and 90 minutes after consuming Beetroot juice (high nitrate supplement) or Placebo, with at least 1-week washout period between the two visits (Kenjale AA et al., J Appl Physiol 2011).
Interventions
- Dietary supplement Beetroot juice
high nitrate supplement - Dietary supplement Placebo drink
placebo
Primary outcome measures
- Forearm blood flow [Time frame: through study completion, an average of 2 year]
Secondary outcome measures (1)
- Flow mediated vasodilation [Time frame: through study completion, an average of 2 year]
Eligibility criteria
Inclusion criteria
- Healthy men and women who are either Caucasian American, Hispanic, or non-Hispanic African American
Exclusion criteria
- Blood pressure higher than or equal to 140/90 mmHg
- BMI > 35kg/m2
- Have a history of cardiovascular, neurological or vascular diseases
- Take prescription medications
- Are smokers
- Are pregnant
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Crossover
- Masking
- Triple blind
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Texas at Austin — Austin
Identifiers
NCT: NCT05188079 · STUDY00001163