Prospective Athlete's Heart Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: No intervention.
- Who it may be relevant to
- Registry conditions: Athlete Heart. Basic parameters: 14 years — 23 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Australia, Belgium
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Prospective Athlete's Heart Study: Long-term Assessment of the Determinants of Cardiac Remodelling and Its Clinical Consequences in Endurance Athletes
Overview
The Pro@Heart (Prospective Athlete's Heart) study is an international multicentre long-term prospective trial. The primary objective of the Pro@Heart study is to investigate the impact of training load (i.e. accurately evaluated in term of type, frequency, duration and intensity) and genotype on the variability of structural, functional and electrical exercise induced cardiac remodeling (EICR) in young competitive endurance athletes. The second objective is to determine how EICR, training load and genotype are associated with physical performance, health benefits and cardiac pathology (e.g. exercise-related cardiomyopathies and arrhythmias) during follow-up over several decades.
Interventions
- Other No intervention
No intervention
Primary outcome measures
- Genotype [Time frame: Baseline]
- Training load [Time frame: Baseline to 20 years]
- Atrial fibrillation [Time frame: Baseline to 20 years]
- Ventricular arrhythmias [Time frame: Baseline to 20 years]
Eligibility criteria
Inclusion criteria
- Males and females aged 14-23 years old
- Athletes competing in endurance sports at national or international level for at least 2 years. Sports include:
- Triathlon
- Cycling
- Distance running (≥ 1500 meters)
- Rowing
- Swimming
- Non athletes engaged in < 3 hours per week of physical activity
Exclusion criteria
- Medical history of cardiovascular disease
- Current smoker of past history of smoking
- Diabetes mellitus
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Belgium · 3 centers
- UZ Antwerpen — Edegem
- Jessa Ziekenhuis Hasselt — Hasselt
- UZ Leuven — Leuven
Australia · 1 center
- Baker Heart and Diabetes Institute — Melbourne
Publications
- De Bosscher R, Dausin C, Janssens K, Bogaert J, Elliott A, Ghekiere O, Van De Heyning CM, Sanders P, Kalman J, Fatkin D, Herbots L, Willems R, Heidbuchel H, La Gerche A, Claessen G; Pro@Heart Consortium. Rationale and design of the PROspective ATHletic Heart (Pro@Heart) study: long-term assessment of the determinants of cardiac remodelling and its clinical consequences in endurance athletes. BMJ O PMID 35368514
Identifiers
NCT: NCT05164328 · 57241