Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Heat Stroke
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Peripheral blood test.
- Who it may be relevant to
- Registry conditions: Heat Stroke, Early Waking, MODS, Proteinosis. Basic parameters: 18 years — 90 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
Heat stroke is a clinical syndrome with high incidence and high fatality rate in summer. Patients with liver, kidney, and brain damage are prone to secondary MODS, and the prognosis is poor due to high medical costs. At present, there is no unified diagnostic criteria for acute liver injury associated with heat stroke, and the commonly used prognosis scores are rarely included in liver injury indicators, which is not good for practicality.
Detailed description
The project intends to collect the peripheral blood of the normal population, the 24 hours after the onset of heat stroke and the patients in the recovery period, to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to search for indicators related to disease deterioration and prognosis, construct and verify the early warning and prognosis evaluation system of the disease.
On this basis, the researcher explore cellular and molecular mediated pathological mechanisms of heat stroke, and then clarify the treatment target of heat stroke.
Interventions
- Diagnostic test Peripheral blood test
Collect peripheral blood to separate and extract plasma, PBMC, and plasma exosomal miRNA, and sequence to find indicators related to disease deterioration and prognosis
Primary outcome measures
- Prognosis [Time frame: Day 30 and Day 90]
Secondary outcome measures (2)
- Heat Stroke-associated kindey injury [Time frame: Day 0, Day 7 and On the day of discharge after improvement]
- Heat Stroke-associated liver injury [Time frame: Day 0, Day 7 and On the day of discharge after improvement]
Eligibility criteria
Inclusion criteria
- The patient voluntarily signs an informed consent form;
- Adult patients who meet the criteria for heat stroke;
- Heat stroke is defined as heat stroke (Heat Stroke, HS) is a serious fatal disease caused by heat injury factors acting on the body, accompanied by multiple organ damage.
Exclusion criteria
- Age <18 years old or >90 years old;
- Patients with advanced tumors, Pregnancy or lactation;
- Patients who missed out during treatment and whose data are incomplete.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- The First Affillated Hospital,the Air Force Medical University — Xi'an
Identifiers
NCT: NCT05155358 · KY20212173