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Recruiting NCT05142124

German Cardiac Arrest Registry

— Observational Out-of-hospital Cardiac Arrest

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Out-of-hospital Cardiac Arrest. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
Germany
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

In Germany, 70.000 to 100.000 patients suffer from out-of-hospital cardiac arrest (OHCA) every year. More than half of these are due to cardiac causes. Despite the medical progress over the last decades, rates of survival with good neurological outcome remain low. For many below-mentioned issues, no adequate evidence from randomized trials is available. Therefore, a systematic and standardized recording of the pre-clinical, clinical and post-clinical treatment course and of the clinical outcomes of OHCA patients is essential to improve patient care. Aim of the German Cardiac Arrest Registry (G-CAR) is to achieve a better understanding of the disease entity, leading to an optimized treatment of OHCA patients. The recorded data include information on demographic and psychosocial aspects, course of the disease, clinical, laboratory and other examinations as well as treatment modalities in patients with OHCA due to a cardiac cause.

Primary outcome measures

  • In hospital mortality [Time frame: until discharge, an average of 2 weeks]
Secondary outcome measures (12)
  • Length of ICU stay [Time frame: until discharge, an average of 2 weeks]
  • Length of hospital stay [Time frame: until discharge, an average of 2 weeks]
  • Mortality [Time frame: Day 30]
  • Mortality [Time frame: Month 6]
  • European Quality of Life 5 Dimensions 5 Level Version (EQ-5D) [Time frame: Month 6]
  • Post Traumatic Stress Syndrome [Time frame: Month 6]
  • Reintegration [Time frame: Month 6]
  • Hospital Anxiety and Depression Scale (HADS) [Time frame: Month 6]
  • Mini Montreal Cognitive Assessment (MoCA) [Time frame: Month 6]
  • Mini Montreal Cognitive Assessment (MoCA) [Time frame: Month 12]
  • Mortality [Time frame: Month 12]
  • European Quality of Life 5 Dimensions 5 Level Version (EQ-5D) [Time frame: Month 12]

Eligibility criteria

Inclusion criteria

  • patients with out-of-hospital cardiac arrest with assumed cardiovascular cause

Exclusion criteria

  • rejection of register participation by patient or legal representative

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-only

Study locations

Germany · 25 centers
  • CHARITE - Universitätsmedizin Berlin - Campus Virchow Klinikum — Berlin
  • SLK-Kliniken Heilbronn - Klinikum am Plattenwald — Bad Friedrichshall
  • Charité Universitätsmedizin Berlin - Deutsches Herzzentrum Berlin — Berlin
  • Universitätsklinikum Bonn — Bonn
  • Bremer Institut für Herz- und Kreislaufforschung am Klinikum Links der Weser — Bremen
  • Herzzentrum der Universität zu Köln — Cologne
  • Herzzentrum Dresden GmbH — Dresden
  • Universitätsklinikum Düsseldorf - Klinik für Kardiologie, Pneumologie und Angiologie — Düsseldorf
  • … and 17 more centers

Publications

  • Poss J, Sinning C, Rossberg M, Hosler N, Ouarrak T, Bottiger BW, Ewen S, Wienbergen H, Voss F, Dutzmann J, Tigges E, Voigt I, Freund A, Desch S, Michels G, Thiele H, Zeymer U; G-CAR Investigators. German Cardiac Arrest Registry (G-CAR)-results of the pilot phase. Clin Res Cardiol. 2025 Oct;114(10):1270-1279. doi: 10.1007/s00392-024-02468-5. Epub 2024 Jun 13. PMID 38869632
  • Poss J, Sinning C, Schreiner I, Apfelbacher C, Drewitz KP, Hosler N, Schneider S, Pieske B, Bottiger BW, Ewen S, Wienbergen H, Kelm M, Bock D, Graf T, Adler C, Dutzmann J, Knie W, Orban M, Zeymer U, Michels G, Thiele H; G-CAR Investigators. German Cardiac Arrest Registry: rationale and design of G-CAR. Clin Res Cardiol. 2023 Apr;112(4):455-463. doi: 10.1007/s00392-022-02044-9. Epub 2022 Jun 21. PMID 35729429

Identifiers

NCT: NCT05142124 · 2020-0396

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗