Cognitive Disorders and Brain Pulse
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Ultrasound examination.
- Who it may be relevant to
- Registry conditions: Neurocognitive Disorders. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Following an initial consultation with a memory, resources and research centre (MRRC) doctor, a day hospital may be prescribed to carry out an assessment of cognitive disorders. Patients are then usually followed up in consultation at least once a year, in the framework of a new day hospital and/or consultations with a MRRC doctor.
Detailed description
Patients will be included at the time of the day hospital assessment. All patients received in the day hospital of the MRRC of Tours will be offered the TPI examination. The patients included will be followed up for a period of 5 years and the TPI examination will be repeated according to the same modalities, as part of their follow-up at the MRRC and/or in the context of a new day hospital if necessary.
Interventions
- Other Ultrasound examination
Ultrasound examination with Tissue Pulsatility Imaging (TPI) TPI is a relatively simple, rapid and non-invasive ultrasound examination which consists of applying a standard ultrasound probe to the acoustic window of the temporal bone to first measure the velocity of the middle cerebral artery in Doppler mode and secondly the cerebral pulsatility (CP) of a region of approximately 10cm2 centred on the middle cerebral artery in B-Echo mode. After collecting the information, the TPI examination will
Primary outcome measures
- maximum amplitude of brain movements [Time frame: one a year from inclusion visit to 5 years]
- mean of brain movements [Time frame: one a year from inclusion visit to 5 years]
- standard deviation of brain movements [Time frame: one a year from inclusion visit to 5 years]
- powers in frequency analysis [Time frame: one a year from inclusion visit to 5 years]
Secondary outcome measures (7)
- Brain pulse [Time frame: one a year from inclusion visit to 5 years]
- Brain pulse [Time frame: one a year from inclusion visit to 5 years]
- Hippocampal volume [Time frame: one a year from inclusion visit to 5 years]
- leucoaraiosis load [Time frame: one a year from inclusion visit to 5 years]
- Carbohydrate metabolism [Time frame: one a year from inclusion visit to 5 years]
- Spinal fluid biomarkers [Time frame: one a year from inclusion visit to 5 years]
- cohort study on brain pulsatility with neuropsychological measures [Time frame: one a year from inclusion visit to 5 years]
Eligibility criteria
Inclusion criteria
- Patient benefiting from a day hospital at the MRRC of the CHU of Tours for assessment of cognitive functions
Exclusion criteria
- Refusal of TPI ultrasound examination
- Patients who opposed to data processing
- Patients under judicial protection
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
France · 1 center
- University hospital — Tours
Identifiers
NCT: NCT05129150 · RIPH3-RNI21-COG PULCE