Resilience and Brain Health of Older Adults (MEDEX-2)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Mindfulness-Based Stress Reduction, Exercise, Mindfulness-Based Stress Reduction + Exercise, Health Education.
- Who it may be relevant to
- Registry conditions: Age-related Cognitive Decline. Basic parameters: from 65 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
This project capitalizes on a natural experiment imposed by the COVID-19 pandemic in conjunction with an extensive set of cognitive, emotional, biological, and neuroimaging variables already collected at multiple time points in older adults participating in a clinical trial of exercise and mindfulness. This project will elucidate the effects of stress on cognitive function and emotional health in later life, including biological measures of Alzheimer Disease risk, stress, and aging, with the ultimate goal of discovering how to mitigate these effects, among older adults who have made and maintained a lifestyle change.
Interventions
- Behavioral Mindfulness-Based Stress Reduction
Mindfulness-Based Stress Reduction - Behavioral Exercise
Exercise - Behavioral Mindfulness-Based Stress Reduction + Exercise
Mindfulness-Based Stress Reduction + Exercise - Behavioral Health Education
Health Education
Primary outcome measures
- Effects of the interventions on changes in cognitive performance [Time frame: Approximately three years]
Eligibility criteria
Inclusion criteria
- Participated in the parent study, Protocol ID #201410093
Exclusion criteria
- Inability to safely continue classes or complete assessments, as per PI discretion
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Factorial
- Masking
- Single blind
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Washington University School of Medicine — St Louis
Identifiers
NCT: NCT05124132 · 201810006 · 1R01AG072694-01A1