Correlation Between Intestinal Microecology Imbalance and Stroke in Young Adults
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Ischemic Stroke, Hemorrhagic Stroke. Basic parameters: 18 years — 45 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Research on Correlation Between Intestinal Microecology Imbalance and the Risk and Prognosis of Stroke in Young Adults
Overview
The relationship between the intestinal microecology and stroke has become a research hotspot in neurology field today. Maintaining the balance of the intestinal microbiota are expected to bring new breakthroughs for prevention and treatment of stroke. In recent years, stroke in young adults has an increasing incidence and a considerable socioeconomic impact because of high disability rate and health-care costs. So there is an urgent need to explore the role and mechanism of intestinal microecology imbalance in stroke, especially in the development and prognosis of stroke in young people. This study aims to use multi-omics technologies, including microbial diversity, metagenomics and metabonomics, to reveal the characteristics of intestinal flora in young stroke patients, identify biomarkers for predicting outcome after stroke and early detection of young people at high risk of stroke, and to further explore the role of gut-brain axis in the pathogenesis of stroke.
Primary outcome measures
- Modified Rankin Scale scores [Time frame: 3 months]
Eligibility criteria
Inclusion criteria
- Clinical diagnosis of acute ischemic or hemorrhagic stroke
- Admission within 12 hours
- Aged 18-45 years
Exclusion criteria
- History of neurological diseases, myocardial infarction, renal and hepatic abnormalities and metabolic diseases
- Combined with tumors, inflammatory bowel disease and other digestive system diseases
- Combined with serious life-threatening diseases or condition
- Any antibiotics, probiotics or prebiotic treatment within 3 months
- Deteriorate and die before collecting faecal samples
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Case-control
Study locations
China · 2 centers
- Shanghai 6th People's Hospital — Shanghai
- Shanghai 6th People's Hospital — Shanghai
Identifiers
NCT: NCT05113043 · 2021-KY-112 (K)