Circulating circRNA in Acute Ischemic Stroke
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Quantitative Real-time polymerase chain reaction.
- Who it may be relevant to
- Registry conditions: Acute Ischemic Stroke. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
Clinical Significance of Circulating circRNA in Acute Ischemic Stroke (CRAST)
Overview
CRAST is to analyze the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke.
Detailed description
Circular RNAs have been highlighted to be involved in the pathological process of ischemic stroke (IS). The purpose of this protocol will investigate the expression pattern of circular RNA (circRNA) by bioinformatics analysis in patients with acute ischemic stroke and healthy control. The candidate circRNA will be verified as biomarkers for the detection and prognosis of acute ischemic stroke. Distinctive expression patterns of circRNA will be identified by individual quantitative real time polymerase chain reaction (qRT-PCR). A diagnostic or predictive model will be established using logistic regression. The panel of these altered circRNAs may be associated with acute IS and could serve as a novel diagnostic or predictive method.
Interventions
- Genetic Quantitative Real-time polymerase chain reaction
Quantitative Real-time polymerase chain reaction of circular RNA (circRNA).
Primary outcome measures
- Differential expression pattern of circRNA [Time frame: 90 days]
Secondary outcome measures (4)
- Dynamic changes of circRNA during the follow-up period [Time frame: 90 days]
- Correlation of circRNA and stroke-associated infection [Time frame: 30 days]
- Correlation of circRNA and inflammatory factors in acute ischemic stroke [Time frame: 7 days]
- Prognostic value of circRNA in acute ischemic stroke [Time frame: 90 days]
Eligibility criteria
Inclusion criteria
- Aged 18 years or older
- Confirmed acute ischemic stroke by a diffusion-weighted imaging-position lesion on magnetic resonance imaging (MRI) and a new lesion on a brain computed tomography (CT) scan
- Within 72 hours of symptom onset
- Good performance status
- Signed an approved informed consents
Exclusion criteria
- a history of hemorrhagic infarction, chronic kidney/liver diseases, peripheral arterial occlusive disease, active malignant disease, and inflammatory or infectious diseases
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Study design
- Observational model
- Case-control
Study locations
China · 1 center
- Department of Neurology — Xuzhou
Identifiers
NCT: NCT05098340 · XYFY2021-KL107-01