Health Benefits of Whole-body Vibration
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Sub Acute Whole Body Vibration Training.
- Who it may be relevant to
- Registry conditions: Whole-body Vibration. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Pilot Investigation on the Health Benefits of Sub Acute (12 Week) Whole-body Vibration Training
Overview
The overall goals of this pilot investigation are to determine 1) the feasibility of conducting home based WBV studies, and 2) to determine if sub-acute home based WBV can improve a) exercise capacity, b) conduit- and micro- vascular function, and c) skeletal muscle function.
Detailed description
Cardiovascular disease (CVD) is the leading cause of death in the world and many comorbid conditions (i.e. diabetes, obesity) can affect overall CVD risk. There is increasing interest into the role that skeletal muscle health plays in mediating CVD risk, particularly in metabolic disease states (ie. obesity and diabetes). Whole body vibration (WBV) has emerged as an exercise mimetic that may be more tolerable than traditional modes of exercise, such as treadmill walking/running or cycling. Similar to traditional exercise modalities, WBV can elicit beneficial metabolic effects. In fact, a single bout of WBV increases circulating concentrations of IL-6, which correspond with the normalization of glucose and insulin in obese individuals. The proposed pilot investigation will provide the foundation to begin understanding the molecular and physiological mechanisms of how sub-acute WBV can improve overall CVD risk. We hypothesize that home based WBV will decrease CVD risk by improving skeletal muscle and vascular function via a decrease in systemic inflammation.
Interventions
- Other Sub Acute Whole Body Vibration Training
Participants will be given a personal vibration plate to take home with them for training which will last for 12 weeks. For the first four weeks, participants will be asked to complete 10 minutes of WBV per day (1 minute on and up to 1 minute of rest), at least 3-4 days per week. At least 24 hours will be recommended in between sessions during weeks 1-4. Beginning at week 5, participants will be asked to increase WBV time to up to 14 minutes and/or reduce the duration of rest. Beginning at week
Primary outcome measures
- Change in VO2 Peak [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
- Change in Flow-Mediated Dilation (FMD) [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
- Change in Skeletal Muscle Mitochondrial Function [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
- Change in Pulse Wave Velocity (PWV) [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
- Change in Post Occlusive Reactive Hyperemia (PORH) [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
- Change in IL-6 [Time frame: pre-treatment baseline and following 12 weeks sub-acute whole-body vibration]
Eligibility criteria
Inclusion criteria
- Men and women (> 18 yrs old)
- All races
Exclusion criteria
- <18 years old
- Clinical diagnosis of hepatic, cardiovascular, or renal disease
- Diabetic complications (i.e. macrovascular, microvascular, or autonomic)
- Pregnancy
- Direct vasoactive medications (i.e. nitrates)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- Augusta University/Georgia Prevention Institute/ Laboratory of Integrative and Exercise Ph — Augusta
Identifiers
NCT: NCT05097885 · 1818010