Nerve Composition of Human Lumbar Dorsal Primary Rami and Its Medial Branch
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Spinal surgery, Histology.
- Who it may be relevant to
- Registry conditions: Lumbar Facet Arthrosis, Nerve Degeneration. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United Kingdom
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of the study is to understand the composition of the nerves supplying the facet joints in low back.
Detailed description
After written informed consent, the nerves supplying the facet joints - lumbar dorsal rami and its medial branches, will be harvested when they are exposed during spinal surgery. These nerves will be fixed, washed and further dissected to enable smaller sections. The cut section will be stained and subjected to analysis of overall cross-sectional area and presence of connective tissue sheaths under light microscope.
Interventions
- Procedure Spinal surgery
In participants who undergo elective lumbar spinal surgery and consented for research, the medial branch and dorsal rami will be harvested for histological analysis. - Other Histology
The harvested nerves will be fixed, cut into smaller sections. Analysis of macroscopic and light microscopic sections will be carried out
Primary outcome measures
- Nerve Histology [Time frame: one year]
Eligibility criteria
Inclusion criteria
- Be aged 18 or over
- be able to give informed consent
- scheduled to undergo lumbar spinal surgery
Exclusion criteria
- Children under 18 years old
- Vulnerable adults
- Adults with incapacity
- Inability to provide informed consent
- History of previous spinal surgery
- history of previous RF ablation for low back pain
- has COVID-19 or displaying symptoms of COVID-19
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
United Kingdom · 1 center
- Woodend Hospital — Aberdeen
Identifiers
NCT: NCT05091112 · 1-076-21