Prediction of Extubation Failure: A Multicenter Prospective Observational Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Mechanical Ventilation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- China
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Official title
The First Affiliated Hospital of Chongqing Medical University
Overview
The investigators intend to collect several variables to predict extubation failure among patients who successfully complete a spontaneous breathing trial, and then develop a scale using simple bedside indicators to predict extubation failure.
Detailed description
Mechanically ventilated patients who successfully completed a spontaneous breathing trial and prepared for extubation are eligible to enroll in this study. The vital signs, arterial blood gas tests, cough strength, cuff leak test, use of noninvasive ventilation et al. are collected. Patients are followed up to postextubation 28-day or discharge. Extubation failure is defined as reintubatin or death within postextubation 7 days. First, we will analyze the data to predict extubation failure. Then, we will combine several easily obtained variables to develop and validate a scale to predict extubation failure. Finally, we explore the predictive power of extubation failure tested by the scale and find the cutoff value to distinguish the low, moderate and high risk of extubation failure.
Primary outcome measures
- Rate of extubation failure [Time frame: From extubation to 48 hours]
- Rate of extubation failure [Time frame: From extubation to 7 days]
- Rate of extubation failure [Time frame: From extubation to 28 days]
Secondary outcome measures (2)
- Rate of mortality [Time frame: From extubation to 28 days]
- ICU stay [Time frame: From extubation to 28 days]
Eligibility criteria
Inclusion criteria
- Prepared for extubation through spontaneous breathing trial;Oral or nasal endotracheal intubation; be at least 18 years old
Exclusion criteria
- Extubation without a spontaneous breathing trial ;Reintubation due to secondary surgery; Tracheotomy
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-only
Study locations
China · 1 center
- The First Affiliated Hospital of Chongqing Medical University — Chongqing
Identifiers
NCT: NCT05069441 · ChongqingMU4