Effect of Hypoxic Conditioning on Cerebrovascular Health in the Elderly
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Hypoxia and/or Exercise.
- Who it may be relevant to
- Registry conditions: Hypoxia, Cerebral Hypoxia, Brain Diseases, Exercise. Basic parameters: 60 years — 80 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
In line with the ever-growing aging of Western populations, the development of preventive strategies to slow down the effects of aging on cardiovascular health represents a major challenge in order to preserve functional capacities and a sufficient quality of life in the elderly. The alteration of vascular function (at the cerebral and systemic level) with aging is an important feature in the clinical picture including a decrease in physical and cognitive capacities. Although physical activity is recognized as an essential means of combating the effects of aging, optimizing its effects by defining the most effective strategies of practice remains a key objective. Offering alternative interventions to exercise training is also necessary for people who are unwilling or unable to engage in a physical activity program. In this context, hypoxic conditioning, alone or in conjunction with rehabilitative exercise training, is a new therapeutic modality with strong preclinical validity, in particular from a cardiovascular standpoint, and used in other pathologies to improve cardiovascular function and exercise performance and quality of life. Our aim is, therefore, to investigate the effect of hypoxic conditioning (alone or in conjunction with exercise training) on cerebrovascular health in the elderly.
Interventions
- Procedure Hypoxia and/or Exercise
Hypoxia at rest versus normoxia at rest; Hypoxia during exercise versus Normoxia during exercise.
Primary outcome measures
- Middle cerebral artery flow velocity [Time frame: Before intervention; right after intervention; 2 months after intervention]
Secondary outcome measures (6)
- Peak oxygen uptake [Time frame: Before intervention; right after intervention; 2 months after intervention]
- Flow-mediated dilation [Time frame: Before intervention; right after intervention; 2 months after intervention]
- Blood pressure [Time frame: Before intervention; right after intervention; 2 months after intervention]
- Sleep [Time frame: Before intervention; right after intervention; 2 months after intervention]
- Cognitive function [Time frame: Before intervention; right after intervention; 2 months after intervention]
- Health-related quality of life [Time frame: Before intervention; right after intervention; 2 months after intervention]
Eligibility criteria
Inclusion criteria
- 60 to 80 years of age;
- Being physically inactive (less than 150 min/week of moderate to intense physical activity);
- No chronic cardiovascular, respiratory, metabolic or neuromuscular disease counterindicating an exercise training or hypoxic conditioning program;
- Health coverage;
- Being able to provide written fully informed consent.
Exclusion criteria
- Body-mass index >30 kg/m2;
- Smoking (> cigarettes/day);
- Alcohol use (> 10g/day);
- Mental disorder or history of mental disorder;
- Beta-blockade treatment;
- Inability or refusal to provide informed consent;
- No health coverage
- People exceeding the annual ceiling of allowances received as a result of their participation in other clinical trials;
- People deprived of freedom by judicial or administrative decision;
- People subject to legal protection, who cannot be included in clinical trials.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Randomized
- Model
- Parallel assignment
- Masking
- Quadruple blind
- Primary purpose
- Prevention
Study locations
France · 1 center
- CHU Grenoble Alpes — La Tronche
Identifiers
NCT: NCT05048680 · 38RC20.460