Effects of Pulmonary Diseases and Their Treatment on Cardiac Function
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Cardiac MRI.
- Who it may be relevant to
- Registry conditions: COPD, Bronchial Asthma, Idiopathic Pulmonary Fibrosis. Basic parameters: 18 years — 99 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Germany
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
The Relationship Between Pulmonary and Cardiac Dysfunction and the Cardiac Effects of Pulmonary Treatments: Cardiopulmonary MRI Analysis
Overview
While the bidirectional relationship between the lung and the right heart are well studied, the cardiopulmonary interactions between the lung and the left heart are largely unresearched and not well understood. However, in recent years, there is a growing evidence that partially explains the bidirectional interaction between COPD and left heart. Systemic inflammation with multiorgan involvement is thought to play a role in COPD as a systemic disease. Some therapeutic approaches to COPD also appear to influence these cardiopulmonary interactions. While understanding these interactions is very important for clinicians, scientific data are scarce. Cardiac magnetic resonance imaging (cardiac MRI) is the gold standard for assessing cardiac function and dimensions as well as myocardial inflammation. Despite this excellent suitability of cardiac MRI for the assessment of cardiovascular function, only few studies have investigated cardiac function and myocardial structure in patients with pulmonary disease using cardiac MRI. Such a study is therefore very important for understanding the effects of pulmonary disease and its management on the heart. The objective is to determine cardiac function in patients with pulmonary disease and to analyze the cardiovascular effects of the treatment of the pulmonary disease. Specifically, the following will be studied: * Using cardiac MRI: Cardiac function and volumes and indications of myocardial fibrosis and edema in patients with chronic pulmonary disease at the time of first diagnosis. * the vascular function of pulmonary arteries in these patients, also using cardiac MRI * the relationship between pulmonary function parameters and cardiac dysfunction to identify patients at increased risk, if applicable. * Echocardiographic assessment of left heart including strain analysis. * the course of these cardiovascular parameters (using cardiac MRI and echocardiography) 3-6 months after initiation of guideline-based therapy for pulmonary disease.
Interventions
- Diagnostic test Cardiac MRI
Cardiac MRI and Echocardiography before treatment initiation of pulmonary disease and 3 months thereafter
Primary outcome measures
- left-ventricular end-diastolic volume [Time frame: 3 months]
Secondary outcome measures (3)
- Pulmonary microvascular blood flow (physiological parameter: ml/min/100 ml Lung volume) [Time frame: 3 months]
- Presence of myocardial fibrosis or edema (pathophysiological parameter: yes/no) [Time frame: 3 months]
- Left ventricular global longitudinal strain (physiological parameter) [Time frame: 3 months]
Eligibility criteria
Inclusion criteria
- Patients with chronic lung disease requiring treatment (COPD, asthma, or pulmonary fibrosis).
- Age > 18 years
- Informed consent to participate in the study will sign
Exclusion criteria
- Individuals who are not fully capable of giving consent and understanding the nature, significance and scope of the study.
- Patients with contraindications to MRI examination (eg, pacemaker, severe claustrophobia) or to contrast medium use (severe renal insufficiency or glomerular filtration rate <30 ml/min, known gadolinium contrast medium allergy)
- Patients with atrial fibrillation or other significant cardiac arrhythmias that interfere with cardiac MRI
- Pregnancy and lactation
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Other
Study locations
Germany · 1 center
- University Hospital RWTH Aachen — Aachen
Identifiers
NCT: NCT05042219 · Uniklinik RWTH Aachen