Recruiting NCT05015231
Multiparametric MRI for Assessment of Changes of Renal Hemodynamics After Fistula Closure in Kidney Transplant Patients
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Echocardiography and MRI.
- Who it may be relevant to
- Registry conditions: Kidney Transplantation. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Switzerland
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Multiparametric MRI for Assessment of Changes of Renal Hemodynamics After Fistula Closure in Kidney Transplant Patients: a Pilot Study
Overview
Assessment of changes of renal hemodynamics by multiparametric MRI after closure of AVF access.
Interventions
- Diagnostic test Echocardiography and MRI
Echocardiography and renal MRI before and after fistula closure
Primary outcome measures
- Assessment of changes in renal hemodynamics by multiparametric MRI after closure of AVF access [Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure]
- Assessment of changes in renal hemodynamics by multiparametric MRI after closure of AVF access [Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure]
Secondary outcome measures (1)
- Correlation between AVF access flow and changes as assessed during pneumatic fistula compression with changes in renal hemodynamics after fistula closure [Time frame: evaluation of short term changes within 2 weeks after fistula closure and longterm changes 6 months after fistula closure]
Eligibility criteria
Inclusion criteria
- Written informed consent
- Age > 18 years
- Patients wishing to close the fistula and planned for surgical fistula closure
- eGFR CKD EPI ≥ 45 ml/min/1.73m2 at one year post transplantation
- Stable eGFR within the past 6 months
- Controlled blood pressure
Exclusion criteria
- Kidney Transplantation < 12 months before fistula closure
- Proteinuria > 500mg/d
- Presence of donor specific antibodies
- Rejection within the past 6 months
- BK virus replication within the past 3 months
- Cardiac pacemaker, which is not compatible with MRI
- Claustrophobia
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
Switzerland · 1 center
- University Hospital Zurich — Zurich
Identifiers
NCT: NCT05015231 · 2021-00474