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Recruiting NCT05014893

Neural Mechanisms of Cognitive Assessment and Rehabilitation for Cognitive Decline

No phase Interventional Mild Cognitive Impairment (MCI) Subjective Cognitive Decline (SCD) Aging Healthy

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: multi-modal targeted intervention (e.g., cognitive training, exercise, games).
Who it may be relevant to
Registry conditions: Mild Cognitive Impairment (MCI), Subjective Cognitive Decline (SCD), Aging, Healthy. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Overview

This study investigates the neural mechanisms of cognitive function decline, cognitive assessment methods for subjects with mild cognitive dysfunction (Mild cognitive impairment, MCI, or cognitive decline milder than MCI), and the approaches used to improve and restore cognitive function.

Detailed description

Cognitive assessment tools are used to assess cognitive function of subjects in different cities. Functional and structural MRI and EEG are applied to investigate the neural mechanisms of cognitive function decline and effects of methods to improve and restore cognitive function.

Interventions

  • Combination product multi-modal targeted intervention (e.g., cognitive training, exercise, games)
    The Intervention group will be given recommended interventions tailored to individuals based on their risks (e.g., physical exercise programs, cognitive training, dietary advice, control of blood pressure and cholesterol, healthy diet, control obesity, stop smoking,reduce alcohol excess)

Primary outcome measures

  • Change in Cognitive function (SCD-9) [Time frame: Change from Baseline Cognitive test results at 3 months.]
  • Change in Cognitive function (MoCA) [Time frame: Change from Baseline Cognitive test results at 3 months.]
  • Change in Cognitive function (AD8) [Time frame: Change from Baseline Cognitive test results at 3 months.]
  • Change in Cognitive function (CDR) [Time frame: Change from Baseline Cognitive test results at 3 months.]
Secondary outcome measures (2)
  • Change in Physical capacity (TUG) [Time frame: Change from Baseline physical capacity test results at 3 months.]
  • Change in Physical capacity (chair standing) [Time frame: Change from Baseline physical capacity test results at 3 months.]

Eligibility criteria

Inclusion criteria

  • Adults being able to walk at least a block, and
  • Adults with subjective cognitive decline (SCD), or
  • Adults with mild cognitive impairment (MCI), or
  • Adults with normal cognitive function

Exclusion criteria

  • Clinical diagnosis of dementia
  • Adults who cannot follow the protocal

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: Yes

Study design

Allocation
Randomized
Model
Parallel assignment
Masking
Single blind
Primary purpose
Screening

Study locations

China · 1 center
  • National Research Center for Rehabilitation Technical Aids — Beijing

Identifiers

NCT: NCT05014893 · 201900045

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗