Markers of Infection and Resistance in Invasive Fusariosis
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: biomarkers.
- Who it may be relevant to
- Registry conditions: Fusariosis. Basic parameters: No limits · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- France
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Multicenter Study on Invasive Fusariosis : Looking for Markers of Infection and Resistance
Overview
In recent decades, invasive fusarioses have been emerging fungal pathologies with high mortality. The prognosis depends on the speed of the diagnosis, but currently biological diagnosis is mainly based on fungal culture, no specific biomarker for this microorganism is available in current clinical practice. The genus Fusarium also shows reduced sensitivity to antifungals commonly used and recommended in clinical practice, such as voriconazole or amphotericin B. The main objective of this study is to describe the proportions of different fungal species in positive fungal cultures in patients with invasive fungal infection (IFI) or fungal keratitis. The secondary objectives are the description of the dosage of galactomannans, beta (1,3) -D-glucans and the rate of detection of DNA circulating in case / control groups for the 2 clinical forms studied. In patients with evidence of Fusarium wilt, the study will describe the distribution of the different minimum inhibitory concentrations (MIC) depending on whether or not different antifungals are taken, the vital status at 3 months, and the response or not to treatment. Finally, the presence of genetic markers will be described according to the groups of MIC values.
Interventions
- Diagnostic test biomarkers
galactomannan, betaDglucan, resistance markers
Primary outcome measures
- proportions of different fungal species in positive fungal cultures in patients with invasive fungal infection (IFI) or fungal keratitis [Time frame: 2021-2026]
Eligibility criteria
Inclusion criteria
- Suspicion of invasive fungal infection involving the performance of a blood culture or a skin biopsy or diagnosis of keratitis involving the taking of a cornea sample
- Fungal culture carried out on this sample
- Person having been informed of the research and not having opposed the use of their data
Exclusion criteria
- Clinical diagnosis of superficial fusarium wilt (onychomycosis, etc.)
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Cohort
Study locations
France · 1 center
- CHRU Nancy — Vandœuvre-lès-Nancy
Identifiers
NCT: NCT04937751 · 2020PI202