Genetic Studies of Early-onset Dementia
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Blood draw, Neurocognitive testing, Medical questionnaire.
- Who it may be relevant to
- Registry conditions: Dementia, Early Onset, Alzheimer Dementia (AD), Mild Cognitive Impairment (MCI), Memory Loss. Basic parameters: from 35 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
The aim of this study is to identify genetic factors that contribute to risk and progression of early-onset dementia (loss of memory function before the age of 70 years) across all ethnic groups, including Alzheimer's Disease, mild cognitive impairment and other dementias.
Detailed description
The study population includes individuals with Alzheimer's disease, mild cognitive impairment, other forms of dementia, as well as cognitively healthy individuals with a family history of dementia. Participants include males and females across all racial and ethnic groups.
Interventions
- Genetic Blood draw
Blood draw for identification of genetic variants associated with the development of memory problems - Other Neurocognitive testing
Brief memory test - Other Medical questionnaire
Collection of medical history
Primary outcome measures
- Genetic risk variants associated with early-onset dementia [Time frame: 2 years]
- Changes in blood biomarkers in early-onset dementia [Time frame: 2 years]
Eligibility criteria
Inclusion criteria
- 35 years and older
- Individuals experiencing memory concerns or diagnosed with dementia and their family members that are unrelated healthy controls without dementia.
Exclusion criteria
\- Individuals with competing diagnosis such as Huntington's disease, traumatic brain injury, drug or alcohol abuse, or schizophrenia, etc., unless family members of a dementia affected individual
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
United States · 1 center
- Columbia University Irving Medical Center — New York
Identifiers
NCT: NCT04906863 · AAAQ9793 · 5U24AG056270-07 · 1R01AG064614