Neural Correlates of Real World Spatial Navigation in Humans
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Deep Brain Stimulation, Memory and spatial navigation tasks, Physiological Signals, Questionnaires and Assessments.
- Who it may be relevant to
- Registry conditions: Memory, Delayed. Basic parameters: 12 years — 70 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The purpose of this study is to understand the neural mechanisms that support real world spatial navigation in humans using deep brain recordings and stimulation during virtual reality (VR), augmented reality, and real world memory tasks. We will determine the cognitive (i.e., memory) and behavioral (i.e., body, head, eye position and movement) factors that modulate deep brain activity and the consequent effects of memory-enhancing deep brain stimulation.
Interventions
- Device Deep Brain Stimulation
Deep brain stimulation will be used - Behavioral Memory and spatial navigation tasks
Tasks may include walking around the room, on a treadmill, or in a controlled environment using VR (virtual reality) or AR (augmented reality) technology designed to simulate real-world navigation. Participants may also use Meta Ray-Ban glasses to capture new memories while recording neural activity. - Behavioral Physiological Signals
Physiological signals such as heart rate, respiration, and skin conductance will be monitored while completing lab tasks. Motion capture and eye-tracking may also be used. - Behavioral Questionnaires and Assessments
Participants complete questionnaires and assessments to assess subjective emotional experience.
Primary outcome measures
- Spatial memory [Time frame: Throughout study completion, an average of 2-4 days per year]
- Memory performance change [Time frame: Throughout study completion, an average of 2-4 days per year]
- Oscillatory activity change [Time frame: Throughout study completion, an average of 2-4 days per year]
Eligibility criteria
Inclusion criteria
- 12 years of age or older and has undergone RNS system placement
- Willing to provide informed consent and participate the study
- Ability to read and write English fluently
Exclusion criteria
- Unwilling to provide informed consent
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- N/A
- Model
- Single group
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 2 centers
- University of California, Los Angeles — Los Angeles
- Duke University — Durham
Identifiers
NCT: NCT04874220 · Pro00117931 · U01NS117838 · R01MH124761