Sympathetic Transduction in Obesity-associated Hypertension (OB-HTN)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Neuropeptide Y.
- Who it may be relevant to
- Registry conditions: Hypertension, Obesity. Basic parameters: 18 years — 55 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Sympathetic Neural Patterns and Transduction in Obesity-associated Hypertension
Overview
The purpose of this study is to understand how the nervous system communicates to blood vessels to increase blood pressure during stress. The study will also investigate how hypertension and obesity influence the nervous system and vascular function. The study will involve measuring sympathetic nervous system activity and blood flow during common laboratory physiological stress protocols (e.g. hypoxia, exercise), and in response to infusion of drugs that cause vasodilation or vasoconstriction.
Interventions
- Drug Neuropeptide Y
intra-arterial infusion of neuropeptide Y
Primary outcome measures
- Blood flow measured by doppler ultrasound [Time frame: Acutely on the day of study]
- Muscle sympathetic nervous system activity [Time frame: Acutely on the day of study]
Eligibility criteria
Inclusion criteria
- Control - BMI<30, age 18-55
- Hypertensive - BMI<30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring Obese- BMI>30, age 18-55 Obese-hypertensive- BMI>30, age 18-55, diagnosis of hypertension by 24-hour ambulatory blood pressure monitoring
Exclusion criteria
All groups - presence of other significant cardiovascular disease, renal disease, history of smoking, diabetes,
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Allocation
- Non-randomized
- Model
- Parallel assignment
- Masking
- Open label
- Primary purpose
- Basic science
Study locations
United States · 1 center
- University of Texas Southwestern Medical Center — Dallas
Identifiers
NCT: NCT04838678 · STU2020-0749