Relapse Prevention and Changing Habits in Anorexia Nervosa
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Relapse Prevention and Changing Habits (REACH+).
- Who it may be relevant to
- Registry conditions: Anorexia Nervosa. Basic parameters: 18 years — 60 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- United States
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Official title
Optimizing Relapse Prevention and Changing Habits in Anorexia Nervosa
Overview
This study aims to optimize a treatment package for the relapse prevention treatment of AN. In the Preparation Phase, we examined accessibility and feasibility of the treatment package. In the current Optimization Phase, we will identify which components of treatment contribute to positive outcomes after acute hospitalization. We will carefully evaluate maintenance of remission, measured by rate of weight loss and end-of-trial status.
Detailed description
While many approaches to reducing relapse after hospital care have been tried, there is little information about which treatment elements confer benefit. This trial, Relapse Prevention and Changing Habits (REACH+), targets the habitual control of maladaptive behavior to support patients with AN in the 6 months after acute treatment, a time of high vulnerability to relapse. Each component of REACH+ addresses a question that is critical to answer in order to identify and optimize a relapse prevention treatment package that balances efficacy and burden. We will test the acceptability and feasibility of 5 components that together target habits: 1) Behavioral, 2) Cognitive, 3)Motivation, 4) Food Monitoring, and 5) Skill Consolidation. In the Preparation Phase, 10 participants were enrolled, and accessibility and feasibility of the treatment package was examined. The current Optimization Phase includes a finalized treatment manual (including an online platform) and will test each component's contribution to weight maintenance after acute treatment.
Interventions
- Behavioral Relapse Prevention and Changing Habits (REACH+)
Psychotherapy
Primary outcome measures
- Weight maintenance [Time frame: 6-month end of treatment]
Secondary outcome measures (5)
- Habit strength [Time frame: 6-month end of treatment]
- Weight/shape distortion [Time frame: 6-month end of treatment]
- Intrinsic motivation [Time frame: 6-month end of treatment]
- Dietary restriction [Time frame: 6-month end of treatment]
- Skill consolidation [Time frame: 6-month end of treatment]
Eligibility criteria
Inclusion criteria
- Diagnosis of Anorexia Nervosa at hospital admission
- Medically Stable
- Internet capability with videoconferencing
- Weight restored (BMI > 19 kg/m2) at New York State Psychiatric Institute
Exclusion criteria
- Current substance use or other comorbid disorder requiring specialized treatment
- Pregnancy
- Imminent risk of suicide
- Serious medical illness
- Daily psychotropic medication other than antidepressants (medications that are known effect weight are exclusionary, i.e. stimulants, olanzapine, mirtazapine)
- Participation in outside psychotherapy or structured treatment program (support groups will be allowed). Individuals who are discharged on medications would need to have a non-study psychiatrist.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Allocation
- Randomized
- Model
- Factorial
- Masking
- Open label
- Primary purpose
- Treatment
Study locations
United States · 1 center
- New York State Psychiatric Institute — New York
Publications
- Steinglass JE, Attia E, Glasofer DR, Wang Y, Ruggiero J, Walsh BT, Thomas JG. Optimizing relapse prevention and changing habits (REACH+) in anorexia nervosa. Int J Eat Disord. 2022 Jun;55(6):851-857. doi: 10.1002/eat.23724. Epub 2022 Apr 30. PMID 35488866
Identifiers
NCT: NCT04810624 · 8110 · R34MH127180