Immuno-inflammation in the Acute Phase of an Ischaemic Cerebral Accident Managed by Decompressive Hemicraniectomy: a Case-control Study
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- The protocol lists: Decompressive hemicraniectomy, neurosurgical operation.
- Who it may be relevant to
- Registry conditions: Ischemic Cerebrovascular Accident. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Center list to be confirmed — check the primary protocol.
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
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Overview
The objective of the NEUTROSURGERY study is to describe the local and locoregional immuno-inflammatory activity in patients suffering from malignant sylvian ischaemic cerebral accident and treated with decompressive hemicraniectomy compared to a control population of patients to be operated on in neurosurgery for another neurosurgical pathology.
Interventions
- Procedure Decompressive hemicraniectomy
Decompressive hemicraniectomy in the context of a malignat sylvian ischaemic cerebral accident - Procedure neurosurgical operation
neurosurgical operation on which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.
Primary outcome measures
- neutrophil polynuclear cells levels [Time frame: Day 0]
Eligibility criteria
Inclusion Criteria Patients:
- Collegial indication given by a neurologist, a neuroreanimator and a neurosurgeon for HD in the context of a malignant sylvian AIC.
Inclusion Criteria Control:
\- For neurosurgical operations in which cranial, meningeal, vascular (branch of the middle meningeal artery) or cerebral bone tissue is not preserved during the surgical approach.
Non-inclusion Criteria Patients:
- HD carried out in a context of acute cerebral haemorrhage
- Pre-existing neurological disability: modified Rankin score > 2
- Patient benefiting from a legal protection measure
Non-inclusion Criteria Controls:
- Patient to be operated on for an acute vascular condition: meningeal haemorrhage, subdural or extradural haemorrhage, intra parenchymal haemorrhage.
- Patient operated on for an osteomeningeal pathology present at the approach site.
- Patient operated on for an infectious cranial or neuro-meningeal pathology.
- Patient to be operated on as a result of an intracranial traumatic condition
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: No
Study design
- Observational model
- Case-control
Study locations
Center list to be confirmed — check the primary protocol.
Identifiers
NCT: NCT04763161 · BMR_2021_2