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Recruiting NCT04691037

CCTA Improves Clinical Management of Stable Chest Pain

— Observational Coronary Computed Tomography Angiography Stable Chest Pain Optimal Medical Therapy Invasive Coronary Angiography

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
The protocol lists: CCTA.
Who it may be relevant to
Registry conditions: Coronary Computed Tomography Angiography, Stable Chest Pain, Optimal Medical Therapy, Invasive Coronary Angiography. Basic parameters: from 18 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

Unsure about the terms? Read our patient guide →

Official title

Improving the Clinical Management of Stable Chest Pain Based on Imaging: a Registry of Computed Tomography Coronary Angiography

Overview

The investigator aims to prospectively enroll patients who were referred for coronary computed tomography angiography (CCTA) for the assessment of stable chest pain (SCP) suspected of obstructive coronary artery disease (CAD). All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary. This study will determine if CCTA-based imaging evaluation can provide more informaton to improve clinical management for SCP, including fewer MACE and better decision-making of downstream investigations and therapeutic interventions.

Interventions

  • Diagnostic test CCTA
    All patients underwent CCTA according to established guidelines and local institutional protocols. The imaging data were evaluated using different image post-processing software to comprehensively analyse anatomical, functional and histological information of coronary.

Primary outcome measures

  • Major adverse cardiovascular events [Time frame: 10 years]
Secondary outcome measures (7)
  • Invasive coronary angiography [Time frame: 10 years]
  • Medication prescription [Time frame: 10 years]
  • Coronary revascularization [Time frame: 10 years]
  • Number of Participants with Death [Time frame: 10 years]
  • Number of Participants with Stroke [Time frame: 3 years]
  • Number of Participants with Cardiac death [Time frame: 10 years]
  • Number of Participants with Myocardial infarction [Time frame: 10 years]

Eligibility criteria

Inclusion criteria

  • symptomatic patients with SCP suspected of obstructive CAD.
  • referred for CCTA for the assessment of SCP.
  • ≥18 years of age.
  • signed informed consent.

Exclusion criteria

  • acute coronary syndromes
  • previous CAD or coronary revascularization
  • nonsinus rhythm
  • cardiomyopathy, valvular disease, congenital heart disease or left cardiac insufficiency because of other reasons

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Cohort

Study locations

China · 4 centers
  • Beijing Chaoyang Hospital — Beijing
  • Hebei Petrochina Central Hospital — Langfang
  • Tianjin Chest Hospital — Tianjin
  • Tianjin First Central Hospital — Tianjin

Publications

  • Wang P, Chen T, He M, Xin T, Wang C, Zhao J, Tan Y, Zhou J. Comparison of coronary artery calcium score-based and all-coronary computed tomography angiography strategies in patients with stable chest pain and risk factor-weighted clinical likelihood of 5-15. BMC Med Imaging. 2026 Feb 20;26(1):161. doi: 10.1186/s12880-026-02232-3. PMID 41721263
  • Tan Y, Liu C, Chen T, Li Y, Wang C, Zhao J, Zhou J. Coronary Artery Calcium Score-Weighted Clinical Likelihood Model Performance in Patients with Stable Chest Pain and Coronary Artery Calcium Scores of Zero. Rev Cardiovasc Med. 2024 Mar 4;25(3):85. doi: 10.31083/j.rcm2503085. eCollection 2024 Mar. PMID 39076944
  • Zhou J, Li C, Zhang H, Liu C, Yang J, Zhao J, Hou Y, Tan Y, Wang H, Li Y, Xie C, Wang M, Wang C, Zhang E, Wang S, Zhao P, Shan D, Liang S, Gao Y, Huo Y, Cong H, Guo Z, Chen Y. Association between Coronary Artery Disease Reporting and Data System-recommended Post-Coronary CT Angiography Management and Clinical Outcomes in Patients with Stable Chest Pain from a Chinese Registry. Radiology. 2023 Jun; PMID 37310243
  • Jiang H, Feng J, Feng C, Ren P, Ren K, Jin Y, Zhou J. Validation and Comparison of PROMISE and CONFIRM Model to Predict High-Risk Coronary Artery Disease in Symptomatic and Diabetes Mellitus Patients. Rev Cardiovasc Med. 2022 Mar 1;23(3):80. doi: 10.31083/j.rcm2303080. PMID 35345247

Identifiers

NCT: NCT04691037 · 2017-KY-004

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗