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Recruiting NCT04660487

Relationship Between "FODMAPs" and "GVHD"

— Observational Graft Versus Host Disease

For patients and families

In plain language

An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.

What is being studied
This is an observational study: the protocol does not assign a study treatment.
Who it may be relevant to
Registry conditions: Graft Versus Host Disease. Basic parameters: 18 years — 60 years · All.
What needs checking
Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
Where it takes place
China
Next step
Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →

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Official title

Relationship Between the Utilization and Degradation Rate of "FODMAPs" by Intestinal Flora and "GVHD"

Overview

With the stem cell transplanting increasing, patients which effected with "GVHD" were also increased. To evaluation the relationship between "FODMAPs" and "GVHD", Bone marrow transplant patients were recruited.

Detailed description

The feces were collected from the patients who had been successfully transplanted after bone marrow transplantation. After 24 hours of culture in the culture medium, the degradation rate of "FODMAPs" was detected, and the relationship between the degradation rate and the occurrence time and degree of "GVHD" was observed

Primary outcome measures

  • Occurrence of GVHD [Time frame: 90 days]

Eligibility criteria

Inclusion criteria

  • Clinical diagnosis of "AML","ALL","MDS" or "MM" Disease;
  • Must be treated with bone marrow transplantation;
  • The transplanted bone marrow was successfully planted

Exclusion criteria

  • Gastrointestinal diseases；
  • Age>60; or Age<10；
  • Probiotics or prebiotics were taken before enrollment

Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.

Healthy volunteers: No

Study design

Observational model
Case-only

Study locations

China · 1 center
  • 中国 — Suzhou

Identifiers

NCT: NCT04660487 · FODMAPS202001

Primary sources (government registries)

View this study on ClinicalTrials.gov ↗