Prospective Study on Patients With Obstructive Sleep Apnea in Hong Kong (PrOSA)
For patients and families
In plain language
An automatic summary of structured registry data. It is an orientation aid, not a substitute for the official protocol or a physician assessment.
- What is being studied
- This is an observational study: the protocol does not assign a study treatment.
- Who it may be relevant to
- Registry conditions: Obstructive Sleep Apnea. Basic parameters: from 18 years · All.
- What needs checking
- Age, condition and sex are only basic indicators. Prior treatment, laboratory values and other mandatory requirements appear in the eligibility criteria below.
- Where it takes place
- Hong Kong
- Next step
- Save the trial, show it to the treating physician, and confirm current recruitment with the study center. Costs, documents and travel →
Unsure about the terms? Read our patient guide →
Overview
Obstructive sleep apnea syndrome (OSAS) is a common disorder with prevalence rates of at least 4% among the middle-aged male Caucasians and Hong Kong (HK) Chinese populations. It is characterized by repetitive episodes of upper airway obstruction, causing intermittent hypoxia, sleep fragmentation, disabling daytime sleepiness, impaired cognitive function and poor health status. OSAS patients are at increased risks of non-fatal and fatal cardiovascular morbidity and mortality including sudden death, in addition to being more prone to road traffic accidents. However, there is no long term follow up of patients with OSAS on the incidence of cardiovascular disease, compliance on the therapy and the impact of the quality of life. The study is aimed to carry out a prospective observational study assessing the role of OSAS as a possible cause of increased cardiovascular risk and cognitive decline.
Primary outcome measures
- incidence of Cardiovascular disease [Time frame: 5 years]
Secondary outcome measures (2)
- Change of Montreal Cognitive Assessment score (MoCA) [Time frame: 5 years]
- Change of Epworth Sleepiness Score [Time frame: 5 years]
Eligibility criteria
Inclusion criteria
- suspected obstructive sleep apnea syndrome
- aged 18 or above
- must be able to speak, read and understand Chinese or English
- possess the ability to respond to questions and follow instructions.
Exclusion criteria
- already treated sleep apnea,
- a limited life expectancy due to illness unrelated to sleep apnea
- human immunodeficiency virus (HIV),
- advanced renal disease,
- uncontrolled malignancies
- documented alcohol or drug abuse up to 1 year prior to inclusion in the study.
Criteria are shown verbatim from the registry (in English). Final eligibility is always assessed by the study center.
Healthy volunteers: Yes
Study design
- Observational model
- Cohort
Study locations
Hong Kong · 1 center
- Chinese University of Hong — Hong Kong
Identifiers
NCT: NCT04659291 · PrOSA study/2020